摘要
采用GC-MS测定不同质量比(1∶1、1∶2.5、2.5∶1)荆芥-连翘药对及其单味饮片挥发油的化学成分,结合抗痤疮丙酸杆菌、金黄色葡萄球菌和表皮葡萄球菌的作用,以探究荆芥-连翘药对抗痤疮致病菌的配伍意义。结果表明,荆芥挥发油主要含有胡薄荷酮(41.52%)和异薄荷酮(41.62%),连翘挥发油主要含有β-蒎烯(38.93%)、蒎烯(19.46%)和桧烯(15.06%);荆芥-连翘1∶1配伍挥发油成分变化较少,1∶2.5和2.5∶1配伍挥发油成分变化较大,荆芥挥发油成分容易受连翘的影响。荆芥-连翘1∶1配伍对痤疮丙酸杆菌和金黄色葡萄球菌的抑制作用较好,对表皮葡萄球菌有一定程度抑制作用,1∶2.5和2.5∶1配伍挥发油则表现出弱抑菌性,可能与配伍后化学成分发生变化有关。
In order to explore the compatibility of Schizonepetae Herba-Forsythiae Fructus in the treatment of acne,the components of different quality proportions(1∶1,1∶2.5,2.5∶1)of volatile oil were analyzed by gas chromatography-mass spectrometer(GC-MS)and the inhibitory effect on staphylococcus aureus,staphylococcus epidermidis and propionibacterium acnes in vitro were compared.The results show that Schizonepetae Herba volatile oil mainly contained p-Menthone(41.52%)and Menthone(41.62%),and Forsythiae Fructus volatile oil mainly containedβ-Pinene(38.93%),Pinene(19.46%)and Sabinene(15.06%).The components of volatile oil from Schizonepetae Herba-Forsythiae Fructus 1∶1 had litter change,but 1∶2.5 and 2.5∶1 had must change.The components of volatile oil from Schizonepetae Herba were easily affected by Forsythiae Fructus.The volatile oil of Schizonepetae Herba-Forsythiae Fructus 1∶1 had a better inhibitory effect on propionibacterium acnes and staphylococcus aureus,and had a certain inhibitory effect on staphylococcus epidermidis.The volatile oil in ratios of 1∶2.5 and 2.5∶1 showed weak inhibitory,which may be related to the content changes after compatibility.
作者
邱思娃
陈素雯
孔淑霞
蔡延渠
吴燕红
李苑新
QIU Si-wa;CHEN Su-wen;KONG Shu-xia;CAI Yan-qu;WU Yan-hong;LI Yuan-xin(New Drug Research and Development Center,Guangdong Pharmaceutical University,Guangzhou,Guangdong 510006,China)
出处
《日用化学工业》
CAS
北大核心
2021年第6期491-495,共5页
China Surfactant Detergent & Cosmetics
基金
国家自然科学基金(No:81503260)
广东省中医药局科研项目(20202105)。
关键词
药对
荆芥
连翘
挥发油
痤疮
化妆品
pairsl
Schizonepetae Herba
Forsythiae Fructus
volatile oil
Propionibacterium acnes
cosmetic
