摘要
目的观察音乐疗法对阿尔茨海默病(AD)患者行为和心理症状的效果。方法选取2017年4月~2020年4月在大连大学附属新华医院收治的80例AD患者作为研究对象,按照抽签分组法分为试验组(40例)与对照组(40例)。试验组患者采用音乐疗法加美金刚片治疗,对照组患者采用美金刚片治疗,疗程均为16周,比较两者的治疗后神经精神量表(NPI)减分值及治疗前后简易智力状态检查量表(MMSE)评分。结果两组治疗后NPI减分值比较:试验组在妄想、幻觉、激越/攻击、抑郁/心境恶劣、焦虑、情感淡漠/漠不关心六项高于对照组,差异有统计学意义(P<0.05),两组的情感高涨/欣快、脱抑制、易激越/情绪不稳、异常运动、睡眠/夜间行为、食欲和进食障碍减分值比较,差异无统计学意义(P>0.05)。试验组MMSE评分的减分值(即治疗后与治疗前评分差值)[(0.931±0.101)分]高于对照组[(0.272±0.081)分],差异有统计学意义(P<0.05)。结论音乐疗法可以改善AD患者精神行为症状,尤其是激越/攻击、情感淡漠/漠不关心、抑郁/心境恶劣、妄想、幻觉和焦虑方面,也可改善认知功能。
Objective To observe the effect of music therapy on behavioral and psychological symptoms of patients with Alzheimer's disease(AD).Methods Eighty patients with AD treated in Xinhua Hospital Affiliated to Dalian University from April 2017 to April 2020 were selected as research subjects,and were divided into the treatment group(n=40)and the control group(n=40)according to the lot drawing method.Music therapy plus memantine therapy was given to the treatment group,and memantine therapy was given to the control group,with the treatment course of 16 weeks.The decreased score of neuropsychiatric inventory(NPI)after the treatment and the mini-mental state examination(MMSE)score before and after the treatment in the two groups were compared.Results In the comparison of decreased scores of NPI after the treatment in the two groups,the decreased scores of delusion,hallucination,agitation/aggression,depression/dysphoria,anxiety,and apathy/indifference in the treatment group were higher than those in the control group,with statistical differences(P<0.05);there were no statistically significant differences in the decreased scores of elation/euphoria,disinhibition,irritability/lability,motor disturbance,nightime behaviors or appetite/eating between the two groups(P>0.05).The decreased score of MMSE(the difference score between before and after the treatment)in the treatment group was(0.931±0.101)points,higher than that in the control group of(0.272±0.081),with statistical difference(P<0.05).Conclusion Music therapy can improve behavioral and psychological symptoms of patients with AD especially in agitation/aggression,apathy/indifference,depression/dysphoria,delusion,hallucination,and anxiety,and can also improve cognitive function.
作者
李彦玲
王修
单淑珍
王威
LI Yan-ling;WANG Xiu;SHAN Shu-zhen;WANG Wei(Department of Neurology,Xinhua Hospital Affiliated to Dalian University,Liaoning Province,Dalian 116021,China;Graduate School of Dalian University,Liaoning Province,Dalian 116021,China;Department of Rehabilitation,Zhongshan Hospital Affiliated to Dalian University,Liaoning Province,Dalian 116021,China)
出处
《中国当代医药》
CAS
2021年第16期252-254,共3页
China Modern Medicine
基金
辽宁省大连市医学科学研究计划项目(2011020)。
关键词
音乐疗法
阿尔茨海默病
精神行为症状
认知功能
Music therapy
Alzheimer′s disease
Behavioral and psychological symptoms
Cognitive function
