摘要
目的:验证微管解聚蛋白(Stathmin)能否预测口腔鳞癌(oral squamous cell carcinoma,OSCC)患者从多西紫杉醇、顺铂、5氟尿嘧啶(TPF)诱导化疗中远期获益。方法:收集2008年3月—2010年12月入组TPF诱导化疗临床试验的256例OSCC患者的远期随访结果。收集患者肿瘤活检标本,进行Stathmin免疫组织化学染色并评分。根据Stathmin表达评分进行亚组预后分析。采用SPSS 13.0软件包将Stathmin和其他基线特征进行单因素、多因素和Cox回归模型预后分析。结果:Stathmin的表达可预测OSCC患者对TPF诱导化疗的反应,Stathmin低表达的OSCC患者从TPF诱导化疗中获益,而高Stathmin表达的OSCC患者不能获益于TPF诱导化疗。Stathmin的表达是独立的预测因子。结论:Stathmin是独立的预测OSCC诱导化疗疗效的生物标志物,基于Stathmin筛选指导OSCC患者接受TPF诱导化疗的后续临床研究具有重要意义。
PURPOSE: This study analyzed the role of Stathmin as a predictive biomarker on the long-term benefit of TPF induction chemotherapy based on a 11-year follow-up results. METHODS: Long-term follow-up results of 256 oral squamous cell carcinoma(OSCC) patients enrolled in the TPF induction chemotherapy trial were collected. Tumor biopsy specimens were collected for Stathmin immunohistochemical staining and scoring. Subgroup prognosis was analyzed ac-cording to the Stathmin expression. Stathmin and other baseline characteristics were analyzed by univariate, multivariate,and Cox regression model with SPSS 13.0 software package. RESULTS: Stathmin expression predicted the response of TPF induction chemotherapy in OSCC patients. OSCC patients with lower Stathmin expression benefited from TPF induc-tion chemotherapy, while OSCC patients with higher Stathmin expression did not benefit from TPF induction chemothera-py. Stathmin expression was an independent predictor of long-term prognosis. CONCLUSIONS: Stathmin is an independent biomarker for predicting the efficacy of TPF induction chemotherapy in OSCC. Subsequent clinical studies based on Stathmin screening will be meaningful for choice of TPF induction chemotherapy in OSCC.
作者
谈亦然
赵铜超
王丽珍
李江
琚梧桐
朱东旺
张志愿
钟来平
TAN Yi-ran;ZHAO Tong-chao;WANG Li-zhen;LI Jiang;JU Wu-tong;ZHU Dong-wang;ZHANG Zhi-yuan;ZHONG Lai-ping(Department of Oromaxillofacial Head and Neck Oncology,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,College of Stomatology,Shanghai Jiao Tong University,National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology,Shanghai 200011,China;Department of Oral Pathology,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,College of Stomatology,Shanghai Jiao Tong University,National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology,Shanghai 200011,China)
出处
《中国口腔颌面外科杂志》
CAS
2021年第3期217-221,共5页
China Journal of Oral and Maxillofacial Surgery
基金
国家自然科学基金(81972525、81672660)
上海市卫生健康委员会学科带头人计划(2018BR41)
上海交通大学医学院附属第九人民医院临床研究型MDT项目(201916)。
关键词
口腔鳞癌
微管解聚蛋白
诱导化疗
预后
Oral squamous cell carcinoma
Stathmin
Induction chemotherapy
Prognosis
