摘要
人体神经肽Y(hNPY)是由36个氨基酸残基组成的高效神经递质和生物活性多肽,主要分布于中枢神经和外周神经系统及其相关的组织、器官和腺体中,也是人体内源性促食欲因子、神经效应因子和神经内分泌精细调控网络系统中的重要信号分子之一,与多种老年基础疾病的发生、发展、转归及作用机制有密切关系。NPY对老年人生理学功能和生物学效应的影响主要表现在它通过与其特异性受体及受体亚型结合,高效作用于相对应的不同靶点,在身体的各个靶器官发挥对食物摄入刺激、激素合成与分泌、心血管调控作用、体温调节与平衡、神经-内分泌与生物节律以及情绪调控等。因此,本文通过对hNPY的发现与来源、存在与分布、分子质量与结构特征、体内生成途径与释放方式、衍生物设计与合成、hNPY纳米乳体系、基因重组与蛋白融合、单克隆和多克隆抗体、受体激动剂与拮抗剂、检测与分析技术及生物学信息等概述,综述hNPY在老年生物学相关领域的最新研究进展,为未来在老年医学治疗与干预等方面奠定科学理论基础。
Human neuropeptide Y(hNPY)is an efficient neurotransmitter and bioactive polypeptide which is composed of 36 amino acid peptides.It is widely distributed in the central and peripheral nervous system as well as other peripheral tissues,organs,and glands.NPY is one of the important signalling molecules in endogenous appetite-stimulating factors,neuroeffectors and neuroendocrine regulating systems in the body.It is closely related to the occurrence,development,outcome and mechanisms of geriatric-related diseases.The effect of NPY on the physiological and biological function of the elderly is mainly manifested in its binding with its specific receptors and receptor subtypes,and plays role in stimulation of food intake,hormone synthesis and secretion,cardiovascular function,regulation of body temperature,neuroendocrine,biological rhythm and emotion regulation.Therefore,this review intends to summarize the characteristics of hNPY,it would contribute to lay a scientific theoretical foundation for hNPY-related research in geriatric medicine.
作者
丁宇
王媛媛
阮伟清
李小溪
欧阳平
Ding Yu;Wang Yuanyuan;Ruan Weiqing;Li Xiaoxi;Ouyang Ping(Nanfang Hospital,Southern Medical University,Guangzhou 510515)
出处
《国际老年医学杂志》
2021年第3期177-181,共5页
International Journal of Geriatrics
基金
国家自然科学基金项目(81501952)。
