摘要
Surface enhanced Raman spectroscopy(SERS)has emerged as a highly powerful and sensitive tool for molecular analysis.Of the various factors that affect SERS performance,substrate material is the most critical.Since first observed in 1974,noble metals have been the most common substrates for SERS.However,their increasing defects including low selectivity,weak uniformity,and poor stability are all obstacles to these noble metal-based SERS substrates.Recently,due to the unique layer-dependent optical properties and a very large surface-to-volume ratio,two-dimensional(2D)nanomaterials are found to be promising candidates to overcome the shortcomings of a conventional metallic SERS sub-strate.Herein,we concentrate on the latest development and applications of SERS-active 2D nano-materials in our group as well as in other related research studies.The enhancement mechanism of the SERS effect and the development of various SERS-active 2D nanomaterials have been discussed in detail.Eventually,the latest development in 2D nanomaterial-SERS based analytical applications from trace detection of small organic pollutants and macromolecular biomarkers to in-situ cytosensing and in-situ theranostic analysis is introduced.
基金
the financial support from NSFC(21827814 and 21811540027 for Y.Tian,21974049 for T.Zheng)
This work was also supported by Innovation Program of Shanghai Municipal Education Commission(201701070005E00020)
Shanghai Rising-star Program(20QA1403300).
