摘要
目的探讨70岁以上老年人群骨质疏松症与心血管疾病危险因素的关系。方法选择2018年1月至2019年12月于四川省骨科医院就诊的560例70岁以上骨质疏松症患者纳入骨质疏松组,选取同期于该院就诊的560例骨量正常的老年人纳入对照组,比较并分析两组研究对象血液生化指标与心血管疾病患病情况的关系,采用多因素Logistic回归分析探讨老年人群发生骨质疏松症的影响因素。结果骨质疏松组患者血清总胆固醇(total cholesterol,TC)、同型半胱氨酸(homocysteine,Hcy)、低密度脂蛋白(low density lipoprotein,LDL)水平均显著高于对照组(均P<0.05),体质指数、高密度脂蛋白(high density lipoprotein,HDL)均显著低于对照组(均P<0.05);骨质疏松组患者合并高血压、高脂血症、冠心病、糖尿病的占比均显著高于对照组(均P<0.05)。多因素Logistic回归分析结果显示,合并高血压、高脂血症、冠心病、糖尿病以及血清TC、LDL、Hcy水平升高均是老年人群发生骨质疏松症的危险因素(均P<0.05),HDL是老年人群发生骨质疏松症的保护因素(P=0.014)。结论老年人群发生骨质疏松症与多种心血管疾病危险因素有关,应积极关注骨密度值,有针对性的预防骨质疏松症的发生。
Objective To explore the relationship between osteoporosis and risk factors of cardiovascular disease in elderly patients over 70 years old.Method A total of 560 patients over 70 years old with osteoporosis who were admitted to Sichuan Province Orthopaedic Hospital from January 2018 to December 2019 were included in osteoporosis group,and 560 elderly patients with normal bone mass who were admitted to the hospital during the same period were included in control group.The relationship between the blood biochemical indexes and the incidence of cardiovascular diseases between the two groups was compared and analyzed.Multivariate Logistic regression analysis was used to explore the influencing factors of osteoporosis in the elderly population.Result Serum levels of total cholesterol(TC),homocysteine(Hcy)and low density lipoprotein(LDL)in osteoporosis group were significantly higher than those in control group(all P<0.05),body mass index and high density lipoprotein(HDL)were significantly lower than those in control group(all P<0.05).The proportions of hypertension,hyperlipidemia,coronary heart disease and diabetes in osteoporosis group were significantly higher than those in control group(all P<0.05).Multivariate Logistic regression analysis showed that hypertension,hyperlipidemia,coronary heart disease,diabetes mellitus and elevated serum TC,LDL and Hcy levels were all risk factors for osteoporosis in the elderly population(all P<0.05),and HDL was a protective factor for osteoporosis in the elderly population(all P<0.05).Conclusion Osteoporosis in the elderly population is related to a variety of cardiovascular disease risk factors,we should actively pay attention to the value of bone mineral density,targeted prevention of osteoporosis.
作者
苟静
岳建彪
李霞
Gou Jing;Yue Jianbiao;Li Xia(Department of Internal Medicine,Sichuan Province Orthopedic Hospital,Chengdu 610000,China)
出处
《中国医学前沿杂志（电子版）》
2021年第5期70-73,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
关键词
骨质疏松
心血管疾病
危险因素
老年人群
Osteoporosis
Cardiovascular disease
Risk factors
Elderly population
