摘要
目的:探讨经尿道前列腺等离子电切术(PKRP)联合内分泌治疗在晚期前列腺癌中的效果。方法:选取笔者所在医院泌尿外科2019年6月-2020年6月收治并确诊为晚期前列腺癌患者72例作为研究对象,根据治疗方法不同,将患者分为对照组(单纯行内分泌治疗)及联合组(PKRP联合内分泌治疗),各36例。比较两组治疗前、治疗3个月后国际前列腺症状评分表(IPSS)评分、血清前列腺特异性抗原(PSA)、最大尿流率(Qmax)、残余尿量(RUV)和生活质量评分表(QOL)评分。结果:治疗前两组IPSS评分、PSA水平比较差异无统计学意义(P>0.05);治疗3个月后,联合组IPSS评分、PSA水平均低于对照组,差异均有统计学意义(P<0.05)。治疗前两组Qmax、RUV比较差异无统计学意义(P>0.05),治疗3个月后,联合组Qmax高于对照组,RUV低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组各项生活质量评分比较差异无统计学意义(P>0.05),治疗3个月后,联合组评分均高于对照组,差异均有统计学意义(P<0.05)。结论:经尿道前列腺等离子电切术联合内分泌治疗晚期前列腺癌的效果明显优于单纯内分泌治疗,能有效改善患者排尿困难症状,提高患者生活质量。
Objective:To explore the effect of transurethral plasma resection (PKRP) combined with endocrine therapy in advanced prostate cancer.Method:A total of 72 patients diagnosed with advanced prostate cancer admitted to the Department of Urology of the author’s hospital from June 2019 to June 2020 were selected as the research subjects,according to different treatment methods,the patients were divided into the control group (endocrine therapy alone) and the combined group (PKRP combined with endocrine therapy),with 36 cases in each group.The scores of International Prostate Symptomatic Scale (IPSS),serum prostate-specific antigen (PSA),maximum urine flow rate (Qmax),residual urine volume (RUV) and quality of life scale (QOL) were compared between the two groups before treatment and 3 months after treatment.Result:Before treatment,there were no significant differences in IPSS score and PSA level between the two groups (P>0.05),after 3 months of treatment,the IPSS score and PSA level in the combined group were lower than those in the control group,the differences were statistically significant (P<0.05).Before treatment,there were no significant differences in Qmax and RUV between the two groups (P>0.05),after 3 months of treatment,the Qmax and RUV in the combined group were higher than those in the control group,the differences were statistically significant (P<0.05).Before treatment,there was no statistically significant difference in the scores of quality of life between the two groups (P>0.05),after 3 months of treatment,scores in the combined group were higher than those in the control group,the differences were statistically significant (P<0.05).Conclusion:The effect of transurethral plasma resection of prostate combined with endocrine therapy for advanced prostate cancer is significantly better than that of endocrine therapy alone,which can effectively improve the symptoms of dysuria and improve the quality of life of patients.
作者
王海荣
WANG Hairong(Beihai People’s Hospital,Beihai 536000,China)
出处
《中外医学研究》
2021年第9期71-73,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
晚期前列腺癌
尿道前列腺等离子电切术
内分泌治疗
生活质量
Advanced prostate cancer
Ttransurethral plasma resection of prostate
Endocrine therapy
Quality of life
