摘要
目的探讨雷贝拉唑四联疗法与枯草杆菌二联活菌配合对慢性糜烂性胃炎患者的临床效果。方法200例慢性糜烂性胃炎患者作为研究对象,按随机数字表法分为实验组和对照组,每组100例。对照组患者采用雷贝拉唑四联疗法,实验组患者采用枯草杆菌二联活菌联合雷贝拉唑四联疗法。比较两组患者治疗效果、症状消退时间、不良反应发生情况。结果实验组患者的治疗总有效率95%(95/100)明显高于对照组的75%(75/100),差异具有统计学意义(χ^(2)=15.6863,P=0.0000<0.05)。实验组患者的上腹隐痛、反酸和呕血消退时间分别为(10.45±3.11)、(10.88±2.81)、(6.92±1.59)d,均明显短于对照组的(14.15±2.82)、(14.68±3.21)、(9.11±1.78)d,差异具有统计学意义(t=8.8134、8.9073、9.1757,P<0.05)。实验组患者不良反应发生率4%明显低于对照组的15%,差异具有统计学意义(χ^(2)=7.0369,P=0.0080<0.05)。结论雷贝拉唑四联疗法联合枯草杆菌二联活菌治疗慢性糜烂性胃炎,能够提高治疗的总有效率,减少临床症状消退时间和发生不良反应的几率,效果理想,具有一定临床价值,安全性好,值得在临床上加以推广及广泛应用。
Objective To discuss the clinical effect of rabeprazole-based quadruple therapy combined with live combined bacillus subtilis and enterococcus faecium granules with multivitamines on patients with chronic erosive gastritis.Methods A total of 200 patients with chronic erosive gastritis as study subjects were divided into experimental group and control group according to random numerical table,with 100 cases in each group.The control group was treated with rabeprazole-based quadruple therapy,and the experimental group was treated with rabeprazole-based quadruple therapy combined with live combined bacillus subtilis and enterococcus faecium granules with multivitamines.The therapeutic effect,time to symptom resolution and occurrence of adverse reactions were compared between the two groups.Results The total effective rate 95%(95/100)of the experimental group was obviously higher than 75%(75/100)of the control group,and the difference was statistically significant(χ^(2)=15.6863,P=0.0000<0.05).The remission time of epigastric pain,acid reflux and hematemesis of the experimental group were(10.45±3.11),(10.88±2.81)and(6.92±1.59)d,which were obviously shorter than(14.15±2.82),(14.68±3.21)and(9.11±1.78)d of the control group,and the difference was statistically significant(t=8.8134,8.9073,9.1757;P<0.05).The incidence of adverse reactions 4%of the experimental group was obviously lower than 15%of the control group,and the difference was statistically significant(χ^(2)=7.0369,P=0.0080<0.05).Conclusion Combination of rabeprazole and live combined bacillus subtilis and enterococcus faecium granules with multivitamines shows certain clinical value and high safety on the treatment of patients with chronic erosive gastritis,which can effectively improve the efficacy,reduce time to symptom resolution and incidence of adverse reactions.It is worthy of clinical promotion and application.
作者
许文君
秦佑胜
XU Wen-jun;QIN You-sheng(Department of Emergency,Zoucheng People’s Hospital,Jining 273500,China)
出处
《中国现代药物应用》
2021年第9期28-30,共3页
Chinese Journal of Modern Drug Application
关键词
枯草杆菌二联活菌
雷贝拉唑
四联疗法
慢性糜烂性胃炎
Live combined bacillus subtilis and enterococcus faecium granules with multivitamines
Rabeprazole
Quadruple therapy
Chronic erosive gastritis
