摘要
恶性肿瘤是严重威胁人类生命的疾病,动物药是中药抗肿瘤复方中的常用药物。目前对于动物类中药的抗肿瘤作用研究已取得初步成果,但还存在着一些缺陷,诸如有效成分不明确,作用机制模糊,多靶点多层次的抗肿瘤作用机制研究难度大,毒性损伤难以预估,研究手段较为单一等。因此,理想的研究手段需参考生物药的基础研究,运用多组学方法整合分析策略,构建基于动物药肽库的高通量药物筛选模型,并建立一套完整的分析体系对动物类中药进行科学评价。本文述评近年来动物类中药的抗癌作用机制及其研究方法的相关进展,对已有研究内容进行总结,有助于拓展动物类中药抗癌研究的新方法与新思路。
Malignant tumor is a disease which threats human life seriously.In traditional Chinese medicine compound,animal drugs are commonly used in treating tumor.Preliminary results have been achieved in researching in antitumor effect of animal traditional Chinese medicine,but defects remain such as:The effective ingredients are unclear;The mechanism of action is vague;It is difficult to study the antitumor effect of multi-target on a multi-level;Toxic damage is unpredictable;The research method is single.In that way,we should use the methods of histology combining with the integrated analysis strategy to build a high-throughput drug screening model based on animal drug peptide library and establish a sound evaluation system for scientific evaluation of animal traditional Chinese medicine referring to the research methods of Biopharmaceutics.Here,we reviews the recent advances in anti-cancer mechanism and research methods of animal traditional Chinese medicine,and summarizes the existing research contents,which will help us to make new ideas for the study of anti-cancer mechanism of animal traditional Chinese medicine.
作者
吴越
李贤煜
杨洪军
WU-Yue;LI Xian-yu;YANG Hong-jun(School of Pharmacy,Nanjing University of Traditional Chinese Medicine,Nanjing 210000,China;Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases,Experimental Research Center,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2021年第4期671-677,共7页
JOURNAL OF BASIC CHINESE MEDICINE
基金
中央公益性研究机构基础研究经费中国中医科学院自主课题(ZZ2018010)-基于质谱成像技术的丹红方抗脑缺血作用的原位特征小分子代谢物分析
中国中医科学院优青项目(ZZ13-YQ-080)-基于非标靶向二维(2D)、三维(3D)质谱成像技术建立“活血方”抗脑缺血作用的药效评价系统。
关键词
中药
动物药
抗癌药物
Traditional Chinese medicine
Animal medicine
Anti-cancer drugs
