摘要
目的研究血清骨桥蛋白(OPN)、可溶性白细胞介素-2受体(sIL-2R)、白细胞介素-2(IL-2)水平对活动性肺结核(ATB)病情及预后判定的意义。方法回顾性分析2018年1月至2019年9月河南大学附属南石医院诊治的108例ATB患者、71例非ATB肺结核病患者的临床资料,另选择同期来本院进行体检健康者68例作为对照组,检测三组研究对象的血清OPN、SIL-2R、IL-2水平,并分析上述因子与ATB患者病情严重程度的关系。所有ATB患者均给予抗结核治疗,随访6个月,分析血清OPN、SIL-2R、IL-2水平与预后的关系及其三者之间的相关性。结果三组研究对象血清OPN、SIL-2R、IL-2水平比较差异有统计学意义(P<0.05),其中ATB患者OPN、SIL-2R水平高于非ATB和对照组,血清IL-2水平低于非ATB组和对照组(P<0.05);轻症ATB患者血清OPN、SIL-2R水平低于重症组患者,血清IL-2水平高于重症组(P<0.05);预后良好ATB患者血清OPN、SIL-2R水平低于预后不佳患者,血清IL-2水平高于预后不佳患者(P<0.05);ATB患者血清OPN水平与SIL-2R水平呈正相关,与IL-2水平呈弱负相关(P<0.05)。结论ATB患者血清OPN、SIL-2R水平明显升高,IL-2水平明显降低,且三者均与疾病严重程度和预后密切相关。
Objective To study the clinical significance of serum osteopontin(OPN),soluble interleukin-2 receptor(sIL-2R)and interleukin-2(IL-2)levels in judging the condition and prognosis of active pulmonary tuberculosis(ATB).Methods The clinical data of 108 patients with ATB and 71 patients with pulmonary tuberculosis but ATB who were diagnosed and treated in Nanshi Hospital Affiliated to Henan University from January 2018 to September 2019 were retrospectively analyzed.Meanwhile,68 healthy people who came to the hospital for physical examination during the same period were selected as the control group.Serum OPN,SIL-2R and IL-2 levels in all groups were analyzed,and the relationship between the above factors and the severity of ATB was analyzed.All patients with ATB were given anti-tuberculosis treatment and were followed up for 6 months.The relationship between serum OPN,SIL-2R and IL-2 levels and the prognosis and correlations among the three were analyzed.Results There were significant differences in serum OPN,sIL-2R and IL-2 levels among the three groups(P<0.05),the levels of OPN and SIL-2R in ATB group were higher than those in non ATB group and control group,and serum IL-2 level was lower in ATB group than in non ATB group(P<0.05).The serum levels of OPN and SIL-2R in mild ATB patients were significantly lower than those in severe ATB patients,while serum IL-2 level were higher in mild ATB patients than those in severe ATB patients(P<0.05).The serum levels of OPN and SIL-2R in patients with good prognosis were lower than those in patients with poor prognosis,while the levels of serum IL-2 in patients with good prognosis were higher than those in patients with poor prognosis(P<0.05).Serum OPN levels in patients with ATB were positively correlated with SIL-2R levels and weakly negatively correlated with IL-2 levels(P<0.05).Conclusions The levels of serum OPN and SIL-2R in ATB patients were significantly increased,while the levels of IL-2 were significantly decreased.These three levels were closely related to the severity and prognosis of the disease.
作者
刘坤
齐红双
李英
潘卫东
Liu Kun;Qi Hongshuang;Li Ying;Pan Weidong(Department of Clinical Laboratory,Nanshi Hospital Affiliated to Henan University,Nanyang 473000,China)
出处
《中国实用医刊》
2021年第4期57-60,共4页
Chinese Journal of Practical Medicine
