摘要
目的探讨不同p53表达乳腺癌临床病理特征及MRI表现,比较其差异。方法收集205例乳腺癌患者的临床病理学特征及MRI表现,依据p53表达状态将其分为p53阳性组(76例)、p53阴性组(129例)。采用x2或Mann-Whitney U检验对两组数据进行统计学分析。结果p53阴性与阳性组淋巴结状态、分子亚型、ER、PR、Her-2表达差异均无统计学意义(P>0.05),而组织学分级、Ki67表达差异均有统计学意义(P<0.05);两组肿瘤形状、边缘、内部强化特征差异无统计学意义(P>0.05),而TIC差异有统计学意义(P<0.05);两组肿瘤LD、ADC值差异无统计学意义(P>0.05),而EER差异有统计学意义(P<0.05)。结论不同p53表达乳腺癌临床病理特征及MRI表现存在差异,p53阳性乳腺癌多表现为组织学分级较高、Ki67高表达、EER较高,这些特征有助于指导临床制定治疗策略和预后判断。
Objective To investigate the clinicopathological characteristics and MRI features in breast cancer with different p53 expression and compare their difference.Methods The clinicopathological characteristics and MRI features of 205 patients were collected,which were divided into the p53 positive group(n=76)and the negative(n=129)according to the expression state of p53.Two groups of data were statistically analyzed using x2 or Mann-Whitney U test.Results No statistically significant difference was found for Lymph node status,molecular subtypes,ER,PR,Her-2 and Ki67 expression between the positive group and the negative(P>0.05),while statistically significant difference was found for histological grading(P<0.05);No statistically significant difference was found for tumor shapes,tumor margins and internal reinforcement features between the two groups(P>0.05),while statistically significant difference was found for TIC(P<0.05);No statistically significant difference was found for LD,ADC;While statistically significant difference was found for EER.Conclusion There is difference in clinicopathological characteristics and MRI features in breast cancer with different p53 expression.Breast cancer with the high expression of p53 is mostly characterized by higher histological grading,Ki67 overexpression and higher EER.These features are helpful to guide clinical treament strategies and prognosis judgment.
作者
王彦龙
肖兰
朱丽娜
黎星
Wang Yanlong;Xiao Lan;Zhu Lina(Department of Mdeical Imaging Center,Gansu Provincal Maternity and Child-care Hospital,Lanzhou,Gansu 730050;Department of MRI,the Tumour Hospital Affiliated to Xinjiang Medical University,Urumchi,Xinjiang 830011,China)
出处
《四川医学》
CAS
2021年第2期162-166,共5页
Sichuan Medical Journal
