摘要
目的观察慢性阻塞性肺疾病(COPD)稳定期患者肺部感染发生状况,并分析其可能的影响因素。方法选取2018年6月—2020年6月四川大学华西医院收治120例COPD稳定期患者,参照相关标准评估患者肺部感染发生状况;设计一般资料调查问卷,详细记录患者性别、年龄等资料,将可能影响因素纳入,经单因素与多因素检验,分析COPD稳定期患者肺部感染发生的影响因素。结果120例COPD稳定期患者经评估结果显示,有23例患者发生肺部感染,发生率为19.17%;经单因素分析结果显示,合并糖尿病、吸烟、抗生素使用时间≥14 d、糖皮质激素使用时间>7 d、血清白蛋白低表达均可能是COPD稳定期患者肺部感染发生的影响因素(OR>1,P<0.05);多因素分析结果显示,合并糖尿病、吸烟、抗生素使用时间≥14 d、血清白蛋白低表达均是肺部感染发生的影响因素(OR>1,P<0.05)。结论COPD稳定期患者肺部感染的发生可能受合并糖尿病、吸烟、抗生素使用时间长、血清白蛋白低表达等因素影响,临床应重点关注上述因素,并给予针对性干预。
Objective To observe the occurrence of pulmonary infection in patients with stable chronic obstructive pulmonary disease(COPD),and to analyze its possible influencing factors.Methods From June 2018 to June 2020,120 patients with stable COPD admitted to West China Hospital of Sichuan University were selected,the occurrence of pulmonary infection in patients was evaluated according to relevant standards;general information questionnaire was designed,the data such as gender and age of the patients were recorded in detail,included the possible influencing factors,the influencing factors of pulmonary infection in stable COPD patients were analyzed by univariate and multivariate tests.Results A total of 120 patients with stable COPD were evaluated,the results showed that 23 patients occurred pulmonary infection,the incidence rate was 19.17%;by single regression analysis,the results showed that combined with diabetes mellitus,smoking,use time of antibiotics≥14 days,use time of glucocorticoid>seven days and low expression of serum albumin were the influencing factors of pulmonary infection(OR>1,P<0.05);then multiple regression model was established and multivariate analysis was conducted,the results showed that combined with diabetes mellitus,smoking,use time of antibiotics≥14 days and low expression of serum albumin were the influencing factors of pulmonary infection(OR>1,P<0.05).Conclusion The occurrence of pulmonary infection in patients with stable COPD may be affected by combined with diabetes mellitus,smoking,prolonged use time of antibiotics and low expression of serum albumin,the above factors should be focused on clinically,and targeted intervention should be given.
作者
贺晓娇
黎思浓
段程
HE Xiaojiao;LI Sinong;DUAN Cheng(Infectious Diseases Center,West China Hospital,Sichuan University,Sichuan Province,Chengdu610041,China)
出处
《中国医药导报》
CAS
2021年第10期96-99,112,共5页
China Medical Herald
关键词
慢性阻塞性肺疾病
稳定期
肺部感染
糖尿病
吸烟
白蛋白
Chronic obstructive pulmonary disease
Stable period
Pulmonary infection
Diabetes mellitus
Smoking
Albumin
