摘要
目的研究腹膜透析患者微炎症和铁负荷的关系。方法选择2019年5月~2020年5月我院收治的腹膜透析患者58例,依据患者发生铁缺乏的情况将其分为A组(功能性铁缺乏组)31例和B组(绝对性铁缺乏组)27例,另外选取30名体检健康者作为C组(对照组)。比较各组红细胞铁含量、ALB、CO2CP、TRF、铁调素(Hepcidin)、血清铁蛋白(SF)等炎性指标和铁代谢指标,分析炎性指标和铁代谢指标的相关性。结果三组红细胞铁含量、ALB、CO2CP、TRF水平比较,差异均有统计学意义(P<0.05);A、B组铁调素、SF、hs-CRP水平比较,差异有统计学意义(P<0.05);相关性分析显示,铁蛋白与hs-CRP、铁调素、IL-6呈正相关(r=0.355、0.645、0.465,P<0.05),与Hb、HCT、红细胞铁含量、TRF、ALB呈负相关(r=-0.480、-0.481、-0.281、-0.434、-0.474,P<0.05);铁调素与SF、IL-6呈正相关(r=0.671、0.345,P<0.05)。结论腹膜透析患者微炎症状态与铁代谢紊乱有关,微炎症状态会加速铁代谢紊乱,在微炎症状态下机体呈缺铁状态。
Objective To study the relationship between microinflammation and iron load in peritoneal dialysis patients.Methods 58 cases of peritoneal dialysis patients admitted to our hospital from May 2019 to May 2020 were selected.According to their iron deficiency,they were divided into group A(functional iron deficiency group)with 31 cases and group B(absolute iron deficiency group)with 27 cases.In addition,30 healthy people on physical examination were selected as group C(control group).Compare the red blood cell iron content,ALB,CO2CP,TRF,Hepcidin,serum ferritin(SF)and other inflammatory indexes and iron metabolism indexes,and analyze the correlation between inflammatory indexes and iron metabolism indexes.Results The three groups of red blood cell iron content,ALB,CO2CP,TRF levels were compared,the differences were statistically significant(P<0.05);Comparison of the levels of hepcidin,SF,and hs-CRP in groups A and B,the difference was statistically significant(P<0.05);Correlation analysis showed that ferritin was positively correlated with hs-CRP,hepcidin,and IL-6(r=0.355,0.645,0.465,P<0.05),and negatively correlated with Hb,HCT,red blood cell iron content,TRF,and ALB(r=-0.480,-0.481,-0.281,-0.434,-0.474,P<0.05);Hepcidin was positively correlated with SF and IL-6(r=0.671,0.345,P<0.05).Conclusion The micro-inflammatory state of peritoneal dialysis patients is related to the disorder of iron metabolism.The micro-inflammatory state accelerates the disorder of iron metabolism.In the micro-inflammatory state,the body is in a state of iron deficiency.
作者
骆楠
LUO Nan(Department of Nephrology,Shijingshan Teaching Hospital of Capital Medical University/Beijing Shijingshan Hospital,Beijing 100043,China)
出处
《医学信息》
2021年第9期131-133,共3页
Journal of Medical Information
关键词
腹膜透析
微炎症
铁负荷
功能性缺铁
Peritoneal dialysis
Microinflammation
Iron load
Functional iron deficiency
