摘要
目的探讨奥司他韦联合连花清瘟颗粒治疗流行性感冒(以下简称流感)的效果观察。方法选取2017年10月至2019年10月在温州市人民医院治疗的流感患者92例为研究对象,按照随机数字表法分为研究组与对照组各46例,对照组采用连花清瘟颗粒治疗,研究组在对照组基础上联合奥司他韦治疗。治疗5 d后,比较两组患者治疗效果及症状消失时间(发热消失时间、咳嗽消失时间、咽痛消失时间);比较治疗前及治疗5 d后两组患者免疫功能[C反应蛋白(CRP)、白细胞介素6(IL-6)、T淋巴细胞亚群(CD4^(+)/CD8^(+))]变化及不良反应发生情况。结果治疗5 d后,研究组患者治疗总有效率[97.83%(45/46)]明显高于对照组[71.74%(33/46)](χ^(2)=12.132,P<0.001);研究组发热消失时间、咳嗽消失时间、咽痛消失时间均明显短于对照组[(2.04±0.51)d比(3.15±1.22)d、(3.25±1.10)d比(4.53±1.36)d、(2.72±0.84)d比(3.95±1.02)d(t=5.693、4.963、6.313,均P<0.001);治疗5 d后,两组患者CRP、IL-6水平均较治疗前显著降低[(9.24±2.51)mg/L比(3.32±2.21)mg/L、(9.21±2.46)mg/L比(5.52±2.10)mg/L、(70.25±25.10)mg/L比(47.57±14.50)mg/L、(69.24±25.43)mg/L比(55.23±16.44)mg/L],且研究组明显低于对照组(t=5.307、3.138,均P<0.001);两组患者CD4^(+)/CD8^(+)水平均较治疗前显著升高[(0.45±0.21)比(1.77±0.59)、(0.46±0.18)比(1.08±0.42)],且研究组明显高于对照组(t=14.295、9.202,均P<0.001);治疗5 d内,两组患者恶心呕吐、皮疹、腹泻发生率比较差异无统计学意义(均P>0.05)。结论流感患者予以奥司他韦联合连花清瘟颗粒,可明显提高其治疗效果及免疫功能,缩短发热、咳嗽及咽痛持续时间。
Objective To investigate the efficacy of oseltamivir combined with LianhuaQingwen granule in the treatment of influenza.Methods Ninety-two patients with influenza who received treatment in Wenzhou People's Hospital from October 2017 to October 2019 were included in this study.They were randomly assigned to receive treatment with Lianhua Qingwen granules(control group,n=46)or Lianhua Qingwen granules combined with oseltamivir(study group,n=46)for 5 d.After treatment,clinical efficacy and symptom disappearance time(fever disappearance time,cough disappearance time,sore throat disappearance time)were compared between the control and study groups.Changes in immune function[C-reactive protein,interleukin-6,T lymphocyte subsets(CD4^(+)/CD8^(+))]after treatment relative to before treatment,and the incidence of adverse reactions were compared between the two groups.Results After treatment,total effective rate in the study group was significantly higher than that in the control group[97.83%(45/46)vs.71.74%(33/46),χ^(2)=12.132,P<0.001].Fever disappearance time,cough disappearance time,sore throat disappearance time in the study group were significantly shorter than those in the control group[(2.04±0.51)d vs.(3.15±1.22)d,(3.25±1.10)d vs.(4.53±1.36)d,(2.72±0.84)d vs.(3.95±1.02)d,t=5.693,4.963,6.313,all P<0.001].After treatment,C-reactive protein and interleukin-6 levels in the study and control groups were significantly decreased compared with before treatment[(9.24±2.51)mg/L vs.(3.32±2.21)mg/L,(9.21±2.46)mg/L vs.(5.52±2.10)mg/L,(70.25±25.10)mg/L vs.(47.57±14.50)mg/L,(69.24±25.43)mg/L vs.(55.23±16.44)mg/L].After treatment,C-reactive protein and interleukin-6 levels in the study group were significantly lower than those in the control group(t=5.307,3.138,all P<0.001).After treatment,the number of CD4^(+)/CD8^(+)cells in the study and control groups was significantly increased compared with before treatment[(0.45±0.21)vs.(1.77±0.59),(0.46±0.18)vs.(1.08±0.42)].After treatment,the number of CD4^(+)/CD8^(+)cells in the study group was significantly higher than that in the control group(t=14.295,9.202,both P<0.001).There were no significant differences in the incidence of nausea,vomiting,rash and diarrhea between the two groups within 5 d of treatment(all P>0.05).Conclusion Oseltamivir combined with Lianhua Qingwen granules exhibits better therapeutic effect than Lianhua Qingwen granules alone.It can strengthen immune function and shorten the durations of fever,cough and sore throat in patients with influenza.
作者
徐梦麟
郑慈
Xu Menglin;Zheng Ci(Department of Respiratory Medicine,Wenzhou People's Hospital,Wenzhou 325000,Zhejiang Province,China)
出处
《中国基层医药》
CAS
2021年第3期340-343,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
流感
人
奥司他韦
连花清瘟颗粒
治疗效果
免疫功能
Influenza,human
Oseltamivir
Lianhua Qingwen granules
Treatment effects
Immune function
