摘要
目的:探讨大环内酯类抗生素应用序贯法治疗儿童肺炎支原体肺炎的效果及对T淋巴细胞亚群的影响。方法:选取2019年1-12月本院收治的120例肺炎支原体肺炎患儿,按照随机数字表法将其分为对照组和研究组,各60例。对照组行红霉素序贯治疗,研究组行阿奇霉素序贯法治疗。对比两组T淋巴细胞亚群、肺功能、血清炎症因子水平。结果:治疗前,两组T淋巴细胞亚群、肺功能、血清炎症因子水平比较,差异均无统计学意义(P>0.05);治疗后,研究组肺功能指标、血清炎症因子水平及T淋巴细胞亚群水平均优于对照组(P<0.05)。研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:大环内酯类抗生素作为儿童肺炎支原体肺炎临床药物干预一线选择方案,与红霉素对比,阿奇霉素序贯法效果更为理想,可改善患儿T淋巴细胞亚群水平、肺功能、炎症反应。
Objective:To investigate the effect of sequential treatment of mycoplasmal pneumonia in children and its effect on T lymphocyte subsets.Method:A total of 120 children with mycoplasma pneumonia admitted to our hospital from January to December 2019 were selected,and they were divided into control group and study group according to random number table method,with 60 cases in each group.The control group received Erythromycin sequential therapy,and the study group received Azithromycin sequential therapy.The levels of serum inflammatory cytokines in lung function of T lymphocyte subsets were compared between the two groups.Result:Before treatment,there were no significant differences in T lymphocyte subsets,lung function and serum inflammatory cytokines between the two groups(P>0.05);after treatment,lung function indexes,serum inflammatory cytokines and T lymphocyte subsets in the study group were better than those in the control group(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion:The Macrolide antibiotics are the first line of choice for clinical drug intervention in children with mycoplasmal pneumonia,compared with Erythromycin,Azithromycin sequential method has more ideal effect,which can improve T lymphocyte subsets,lung function and inflammatory response in children.
作者
赵丹
侯旭东
王琳
ZHAO Dan;HOU Xudong;WANG Lin(Jiamusi Maternal and Child Health Hospital,Jiamusi 154000,China;不详)
出处
《中国医学创新》
CAS
2021年第8期10-13,共4页
Medical Innovation of China
