摘要
目的探讨腹腔镜下全子宫切除术后阴道微生态乳杆菌干预的影响。方法2018年3月—2019年3月间在本院接受腹腔镜下全子宫切除术治疗的患者106例,经随机数表法分为对照组、研究组,各53例。研究组患者在术后1月开始接受乳酸杆菌干预、对照组未采取任何措施。持续干预3个疗程后比较研究组、对照组患者的阴道微生态指标(pH值、菌群密集度、菌群多样性、优势乳杆菌分级),女性性功能指数(FSFI),阴道微生态失衡,阴道炎发生率以及研究组患者乳酸杆菌胶囊相关不良反应发生情况。结果术后2月,研究组、对照组pH值、菌群密集度、菌群多样性、优势乳杆菌分级差异有统计学意义(P<0.05);研究组患者阴道微生态失衡、阴道炎发生率均低于对照组(P<0.05)。术后6月,研究组患者FSFI评分值高于对照组患者(P<0.05)。研究组患者在使用乳酸杆菌胶囊干预期间,未出现明显不良反应。结论腹腔镜下全子宫切除术后早期使用乳酸杆菌干预,在优化阴道微生态、减少阴道炎发生方面具有一定作用,且不会引发明显不良反应。
Objective To observe the effect of Lactobacillus vaginalis intervention after total hysterectomy under laparoscope.Methods One hundred and six patients who received total laparoscopic hysterectomy in our hospital from March 2018 to March 2019 were enrolled and randomly divided into control group or observation group with 53 cases in each group.The patients in observation group received lactobacillus intervention 1 month after surgery,while those in control group received no treatment measures.After 3 courses of intervention,the vaginal microecological indexes(pH,floral density,floral diversity,classification of dominant lactobacillus),female sexual function index(FSFI)and incidences of vaginal microecological imbalance and vaginitis were compared between groups;adverse reactions related to lactobacillus capsules in observation group were analyzed.Results Two months after surgery,there were statistically significant differences in pH,floral density,floral diversity and classification of dominant lactobacillus between the two groups(all P<0.05).The incidences of vaginal microecological imbalance and vaginitis in observation group were lower than those in control group(all P<0.05).Six months after surgery,the FSFI score in observation group was higher than that in control group(P<0.05).During the intervention with lactobacillus capsule,no patients in observation group had significant adverse reactions.Conclusion Lactobacillus intervention in early stage after total hysterectomy under laparoscope plays a certain role in optimizing vaginal microecology and reducing the incidence of vaginitis,and will not cause obvious adverse reactions.
作者
张高丽
张宇飞
ZHANG Gao-li;ZHANG Yu-fei(Department of Obstetrics and Gynecology f Henan Provincial Hospital,Zhengzhou Henan 450000,China;不详)
出处
《中国微生态学杂志》
CAS
CSCD
2021年第1期99-103,共5页
Chinese Journal of Microecology
基金
河南省医学科技攻关计划项目(201702091)。
关键词
腹腔镜
全子宫切除术
乳酸杆菌
阴道微生态
阴道炎
Laparoscopic
Total hysterectomy
Lactobacillus
Vaginal microecology
Vaginitis
