摘要
目的系统评价卵圆孔未闭(PFO)与偏头痛的相关性,为偏头痛的病因研究提供循证依据。方法检索建库至2019年12月中国知网、万方、Pubmed和EMBase等数据库收录的有关PFO与偏头痛相关性的病例对照研究。由2名研究员按纳入及排除标准筛选文献、提取相关资料并对纳入研究进行质量评价,采用Rev Man5.3软件进行Meta分析。结果共纳入相关文献15篇。其中偏头痛2969例,对照组2507例。Meta分析结果表明,PFO可以增加偏头痛的发生率,合并后的OR值为2.2(95%CI:1.62~2.98,P<0.001)。与对照组相比,PFO使非先兆型偏头痛的发生率增加1.35倍(OR=1.35,95%CI:1.11~1.63,P=0.003),使先兆型偏头痛的发生率增加3.17倍(OR=3.17,95%CI:1.75~5.57,P<0.001)。与非先兆型偏头痛相比,先兆型偏头痛PFO的发生率增高2.25倍(OR=2.25,95%CI:1.90~2.90,P<0.01)。结论PFO会增加偏头痛(尤其是先兆型)的发病风险。
Objective To systematically evaluate the correlation between patent foramen ovale(PFO)and migraine,and provide evidence-based evidence for the etiology and treatment of migraine.Methods Case-control studies on the correlation between PFO and migraine were retrieved from CNKI,WanFang,Pubmed,EMBase and other databases from database establishment to December 2019.According to inclusion and exclusion criteria,two researchers selected literatures,extracted relevant data and evaluated the quality of the included studies.Rev Man5.3 software was used for Meta analysis.Results A total of 15 references were selected,including 2969 cases of migraine and 2507 cases of control group.The meta-analysis results showed that PFO could increase the incidence of migraine,and the combined OR value was 2.2(95%CI:1.62-2.98,P<0.001).Compared with the control group,PFO increased the incidence of migraine without aura by 1.35 times(OR=1.35,95%CI:1.11~1.63,P=0.003)and increased the incidence of migraine with aura by 3.17(OR=3.17,95%CI:1.75~5.57,P<0.001).The incidence of PFO in migraines with aura was 2.25 times higher than that in migraines without aura(OR=2.25,95%CI:1.90~2.90,P<0.001).Conclusions PFO may be a risk factor for migraine(especially for with aura).
作者
赵秋霞
刘蓉
周军
董芝芝
陈悦
刘祖林
ZHAO Qiu-xia;LIU Rong;ZHOU Jun;DONG Zhi-zhi;CHEN Yue;LIU Zu-lin(The First College of Clinical Medical Science,China Three Gorges University&Ultrasound Department of Yichang Central People's Hospital,Yichang,Hubei 443003,China)
出处
《中国国境卫生检疫杂志》
CAS
2020年第S01期63-67,共5页
Chinese Journal of Frontier Health and Quarantine
基金
湖北省宜昌市医疗卫生研究项目(A20-2-006)。
关键词
卵圆孔未闭
偏头痛
Patent foramen ovale
Migraine
