摘要
目的探讨动静脉联合序贯应用替罗非班治疗大脑中动脉支架内急性血栓形成的效果。方法对11例大脑中动脉支架扩张成形术中急性血栓形成但未造成血管闭塞患者经动静脉联合序贯应用替罗非班治疗,观察患者血栓形成部位前向血流变化,是否出现治疗后新发梗死灶和新发临床症状。结果 11例患者治疗后前向血流均有所恢复。5例恢复正常前向血流患者中有2例出现新发神经系统症状并伴有支架相关区域新发梗死灶,6例未能恢复正常血流患者中有5例出现新发神经系统症状并伴有支架相关区域新发梗死灶。结论替罗非班动静脉联合序贯应用可有效治疗大脑中动脉支架内急性血栓形成。
Objective To investigate the curative effect of sequential arterial-venous therapy by using tirofiban hydrochloride in treating acute thrombosis within the middle cerebral artery stent. Methods Sequential arterial-venous therapy by using tirofiban hydrochloride was carried out in 11 patients with acute thrombosis within the middle cerebral artery stent but with no vascular occlusion,which occurred during the performance of stent dilatation angioplasty of middle cerebral artery. The changes in forward blood flow at the site of the thrombosis,the postoperative newly-developed cerebral infarction focus and the new clinical symptoms were recorded. Results The postoperative forward blood flow at the site of the thrombosis was improved to some extent in all the 11 patients. Of the 5 patients in whom the forward blood flow restored to normal,2 developed new neurological symptoms associated with newly-developed cerebral infarction foci in stent-related region,while in the 6 patients in whom the forward blood flow did not regain normal status,5 developed new neurological symptoms associated with newly-developed cerebral infarction foci in stent-related region.Conclusion Sequential arterial-venous therapy by using tirofiban hydrochloride can effectively treat acute thrombosis within the middle cerebral artery stent.(J Intervent Radiol,2021,30: 5-8)
作者
苏旭东
姚冬静
刘增品
周存河
刘桂元
于江华
SU Xudong;YAO Dongjing;LIU Zengpin;ZHOU Cunhe;LIU Guiyuan;YU Jianghua(Department of Neurology,Second Hospital of Hebei Medical University,Hebei Provincial Key Laboratory of Neurology,Shijiazhuang,Hebei Province 050000,China)
出处
《介入放射学杂志》
CSCD
北大核心
2021年第1期5-8,共4页
Journal of Interventional Radiology
基金
河北省医学科学研究重点课题计划项目(20160553)。
关键词
替罗非班
大脑中动脉支架
急性血栓形成
溶栓
tirofiban hydrochloride
middle cerebral artery stent
acute thrombosis
thrombolysis
