摘要
目的探讨冠心病心绞痛合并抑郁状态与低T3综合征、同型半胱氨酸(HCY)及C反应蛋白(CRP)的相关性。方法199例冠心病心绞痛患者按照汉密尔顿抑郁量表(HAMD-17)分为观察组(合并抑郁状态)82例和对照组(未合并抑郁状态)117例,比较两组FT3、FT4、T3、T4、TSH、rT3、HCY、CRP水平。结果冠心病心绞痛合并抑郁状态的患病率为41.21%。观察组发生低T3综合征的患病率为29.27%,明显高于对照组(P<0.05),OR为2.13。观察组rT3、HCY、CRP升高例数,以及FT3、T3降低例数,与对照组相比均达到统计学差异(P<0.05)。观察组Pearson相关分析显示:HAMD评分与TSH、HCY显著正相关(P<0.01),与FT4、T4显著负相关(P<0.01);Spearman相关分析表明:HAMD评分与rT3、CRP显著正相关(P<0.01),与FT3、T3显著负相关(P<0.01)。Logistic回归多因素分析显示:两组rT3和CRP升高、FT3降低均达到统计学差异(P<0.05)。ROC曲线分析显示:rT3、CRP的ROC曲线下面积分别为0.87、0.88,FT3的ROC曲线上面积为0.85(均P<0.01)。结论冠心病心绞痛合并抑郁状态与低T3综合征、HCY及CRP具有相关性;rT3、FT3、CRP是冠心病心绞痛合并抑郁状态的危险因素,对预测冠心病心绞痛合并抑郁状态发生的诊断价值中等。
Objective To explore the correlation between Angina pectoris of Coronary heart disease with Depression and Low T3 syndrome,HCY and CRP. Methods According to HAMD-17,199 patients with Angina pectoris of Coronary heart disease were divided into observation group(82 patients with depression)and control group(117 patients without depression). The levels of FT3,FT4,T3,T4,TSH,rT3,HCY and CRP were compared between the two groups. Results The prevalence of Angina pectoris of Coronary heart disease with Depression was 41.21%. The prevalence of Low T3 syndrome in the observation group was 29.27%,significantly higher than that in the control group(P<0.05),and the ratio(OR)was 2.13. The increasing number of rT3,HCY and CRP and the decreasing number of FT3 and T3 in the observation group were significantly higher than those in the control group(P<0.05). Pearson correlation analysis showed that HAMD score was positively correlated with TSH and HCY(P<0.01),negatively correlated with FT4 and T4(P<0.01). Spearman correlation analysis showed that HAMD score was positively correlated with rT3 and CRP(P<0.01),and negatively correlated with FT3 and T3(P<0.01). Logistic regression analysis showed that the differences of rT3,FT3 and CRP between the two groups were statistically significant(P<0.05). ROC curve analysis showed that the area under the ROC curve of RT3 and CRP was 0.87 and 0.88 respectively,and that of FT3 was 0.85(allP<0.01). Conclusion There was correlation between Angina pectoris of Coronary heart disease with Depression and Low T3 syndrome,HCY and CRP. RT3,FT3 and CRP are the risk factors of Angina pectoris of Coronary heart disease with Depression,which have medium diagnostic value for predicting the occurrence of angina pectoris of Coronary heart disease with Depression.
作者
丁怀莹
费玉玲
邵岩
张艳
哈永琴
王保和
DING Huaiying;FEI Yuling;SHAO Yan(Endocrinology Department,Tianjin Binhai New Area hospital of Traditional Chinese Medicine,Tianjin 300451,China)
出处
《国际精神病学杂志》
2020年第6期1196-1200,共5页
Journal Of International Psychiatry
基金
国家“重大新药创制”科技重大专项“十二五”第二批项目子课题《创新药物研究开发技术平台建设-心脑血管疾病中药新药临床评价技术平台及规范研究》(编号:2012ZX09303-010-001)
天津市滨海新区中医医院科技项目《冠心病心绞痛合并抑郁症与低T3综合征相关性的前瞻性巢式病例对照研究》(编号:bhzy201810)。
