摘要
苦参碱具有广泛的生物活性,如保护心、肝、肺、肾、脑、血管作用,对心脏有正性肌力、负性频率、抗心律失常作用,还有升高白细胞,平喘,抗溃疡,抗肝纤维化以及镇静、催眠、镇痛等中枢神经药理作用,也具有抗肿瘤、免疫调节、抗菌、抗病毒、抗炎等药理作用。其中抗肿瘤、心血管保护和治疗病毒性肺炎的药理作用的研究比较深入,希望生产企业开发苦参碱的这些新适应症。苦参碱是一种亲水性的弱碱性药物,易透过生物膜,口服和经皮给药易吸收和分布,约50%原型苦参碱经尿排泄。通过综述苦参碱药动学参数、体内过程,总结苦参碱的药动学研究进展,为合理用药提供参考。推荐将苦参碱试用于病毒性肺炎的治疗。
Matrine has a widespread bioactivities,including protection of heart,liver,lung,kidney,brain and blood vessel,and the effects of positive inotropism,negative chronotropism and antiarrhythmia on heart,and promoting leukocytes,antiasthma,antiulcer,anti-fibrogenesis in liver,and central suppression of sedation,hypnogenesis,analgesia,and antitumor,immunoregulation,antibacteria,anti-virus and anti-inflammation.Amomg them the pharmacologic effects of antitumor,cardiovascular protections,and treatment for viral pulmonitis have be deeply researched,those new indications of matrine are remaining to enterprises to develop.Matrine is a hydrophilic and weakly alkaline drug to easily penetrated through biomembrane.Matrine oral and transdermal administration is easily absorbed and distributed.About 50%prototype matrine is excreted from urine.The pharmacokinetic parameters and process in body of matrine are reviewed,and its research advances on pharmacokinetics is summarized,which provides a reference for rational utilization of matrine.So recommend matrine to try on treatment for viral pulmonitis.We recommend matrine to try on treatment for viral pulmonitis.
作者
张明发
沈雅琴
ZHANG Mingfa;SHEN Yaqin(Shanghai Meiyou Pharmaceutical Co.Ltd.,Shanghai 201204,China)
出处
《药物评价研究》
CAS
2020年第12期2571-2578,共8页
Drug Evaluation Research
关键词
苦参碱
药动学
药理作用
合理用药
病毒性肺炎
matrine
pharmacokinetics
pharmacologic effect
rational use of drug
viral pulmonitis
