摘要
目的研究青蒿(黄花蒿Artemisia annua)干燥地上部分的化学成分。方法综合应用HP-20、硅胶、ODS、Sephadex LH-20和半制备液相等多种色谱学方法进行分离纯化,并根据化合物的理化性质和核磁共振波谱数据进行结构鉴定。结果从青蒿干燥地上部分水提取物中分离得到了5个化合物,分别鉴定为(S)-2,6,11-trimethyl-7,8-dihydro-6H-cyclohepta[b]pyridine-9-carboxylic acid(1)、arteannoide E(2)、蚱蜢酮(3)、(6S,9S)-长寿花糖苷(4)、artemanin B(5)。结论化合物1为新的生物碱,命名为青蒿生物碱;化合物3为首次从蒿属植物中分离得到。
Objective To study the constituents from the dried aboveground part of Artemisia annua.Methods The compounds were isolated and purified by column chromatography of HP-20 macroporous resin,silica gel,ODS,Sephadex LH-20,and semi-preparative RP-HPLC.Their structures were elucidated by physicochemical properties and spectral analyses.Results Five compounds were isolated and identified from the water extract of A.annua,including alkaloid;(S)-2,6,11-trimethyl-7,8-dihydro-6H-cyclohepta[b]pyridine-9-carboxylic acid(1),arteannoide E(2),grasshopper ketone(3),(6S,9S)-roseoside(4)andartemanin B(5).Conclusion Compound 1 is a new alkaloid named arteannine.Compound 3 is identified from Artemisia genus for the first time.
作者
李海波
黄玉欣
秦大鹏
曹亮
王振中
姚新生
于洋
LI Hai-bo;HUANG Yu-xin;QIN Da-peng;CAO Liang;WANG Zhen-zhong;YAO Xin-sheng;YU Yang(Institute of Traditional Chinese Medicine and Natural Products,Jinan University,Guangzhou 510632,China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process,Kanion Pharmaceutical Co.,Ltd.,Lianyungang 222001,China;School of Pharmaceutical Sciences,Shenzhen University Health Science Center,Shenzhen 518060,China)
出处
《中草药》
CAS
CSCD
北大核心
2021年第2期327-330,共4页
Chinese Traditional and Herbal Drugs
基金
重大新药创制科技重大专项“十三五”计划(2018ZX09711001-008-005)
国家自然科学基金重点项目(81630097)。
