摘要
消化系统恶性肿瘤是常见的恶性肿瘤之一,其中胃癌和肠癌的发病率和死亡率较高。外泌体蛋白质是外泌体的重要组成,在肿瘤的生长、转移侵袭和耐药等过程中起关键作用。随着蛋白质组学技术的发展普及,越来越多的外泌体蛋白质的组成和功能相继被揭示,本文以外泌体蛋白质在消化系统恶性肿瘤中的生物学特征、作用机制、诊断和治疗中的价值等方面的研究进展进行综述,以期为消化系统恶性肿瘤的早期诊断、治疗、预后情况提供一些新的思路及方法。
Malignant tumors of the digestive system are one of the common malignant tumors,among which gastric cancer and intestinal cancer have higher morbidity and mortality.Exosomal proteins are an important part of exosomes and play a key role in tumor growth,metastasis,invasion and drug resistance.With the development of proteomics technology,the composition and function of more and more exosomal proteins are revealed.This article summarizes the progress of studies on the characteristics,action mechanism of exosomal protein and its application in the diagnosis and treatment of digestive system malignancies,to provide some new ideas and methods for the early diagnosis and treatment of digestive system malignancies.
作者
许博
孙梦瑶
吴秋雪
张辉
汤庆丰
XU Bo;SUN Meng-yao;WU Qiu-xue;ZHANG Hui;TANG Qing-feng(Dept.of Geriatrics,Putuo Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China;Dept.of Clinical Laboratory and Central Laboratory,Putuo Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China;Interdisciplinary Research Institute,Shanghai University of traditional Chinese medicine,Shanghai 201203,China)
出处
《同济大学学报（医学版）》
CAS
2021年第1期109-115,共7页
Journal of Tongji University(Medical Science)
基金
上海市自然科学基金项目(19ZR1447800)
上海市普陀区卫生系统自主创新科研资助项目(ptkwws201704)
上海市卫生健康委员会卫生行业临床研究专项(20194Y0213)。
关键词
消化系统恶性肿瘤
外泌体蛋白质
生物标志
诊断
治疗
malignant tumor of digestive system
exosomal protein
biomarker
diagnosis
therapy
