摘要
目的探讨血清糖类抗原125(CA125)、氨基末端脑钠尿肽前体(NT⁃proBNP)和尿酸(UA)联合检测对慢性心力衰竭(简称心衰)合并心房颤动(简称房颤)患者预后的评估价值。方法纳入245例慢性心衰患者(慢性心衰组)和199例慢性心衰合并房颤患者(慢性心衰合并房颤组),比较两组患者血清CA125、NT⁃proBNP、UA水平。根据出院后30天内是否发生终点事件将199例慢性心衰合并房颤患者分为非终点事件组(142例)和终点事件组(57例),比较两组患者血清CA125、NT⁃proBNP、UA水平。采用Spearman相关分析评估血清CA125、NT⁃proBNP、UA与慢性心衰合并房颤患者终点事件的相关性,采用受试者工作特征(ROC)曲线分析血清CA125、NT⁃proBNP、UA对慢性心衰合并房颤患者终点事件的预测价值。结果慢性心衰合并房颤组患者血清CA125、NT⁃proBNP、UA水平均高于慢性心衰组(P<0.05)。终点事件组患者血清CA125、NT⁃proBNP、UA水平均高于非终点事件组(P<0.05)。Spearman相关分析结果显示,血清CA125、NT⁃proBNP、UA与慢性心衰合并房颤患者的终点事件均呈正相关(r=0.281、0.273、0.417,P均<0.001)。ROC曲线分析结果显示,血清UA对慢性心衰合并房颤患者终点事件的预测价值明显优于血清CA125,血清NT⁃proBNP明显优于血清UA,血清CA125、NT⁃proBNP和UA三者联合检测明显优于各项指标单独检测(P<0.05)。结论血清CA125、NT⁃proBNP、UA在慢性心衰合并房颤患者中呈高水平状态,且与其预后明显相关,三者联合检测对其预后具有较高的评估价值。
Objective To explore the value of combined detection of serum carbohydrate antigen 125(CA125),N⁃terminal pro⁃brain natriuretic peptide(NT⁃proBNP)and uric acid(UA)in prognosis evaluation of patients with chronic heart failure(CHF)and atrial fibrillation(AF).Methods A total of 245 patients with CHF(CHF group)and 199 patients with CHF and AF(CHF and AF group)were concluded.Serum CA125,NT⁃proBNP and UA levels were compared between above two groups.Meanwhile,199 patients with CHF and AF were divided into non⁃end⁃point event group(142 cases)and end⁃point event group(57 cases)according to whether end⁃point events occurded or not within 30 days after discharge.Serum CA125,NT⁃proBNP and UA levels were compared between above two groups.Spearman correlation analysis was used to explore the correlation between serum CA125,NT⁃proBNP,UA and end⁃point events of patients with CHF and AF.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum CA125,NT⁃proBNP and UA for end⁃point events in patients with CHF and AF.Results Serum CA125,NT⁃proBNP and UA levels in CHF and AF group were significantly higher than those in CHF group(P<0.05).Serum CA125,NT⁃proBNP and UA levels in end⁃point event group were significantly higher than those in non⁃end⁃point event group(P<0.05).Spearman correlation analysis showed that serum CA125,NT⁃proBNP and UA were positively correlated with end⁃point events in patients with CHF and AF(r=0.281,0.273,0.417,all P<0.001).ROC curve analysis showed that the value of serum UA in predicting end⁃point events in patients with CHF and AF was significantly better than serum CA125,serum NT⁃proBNP was significantly better than serum UA,and combined detection of serum CA125,NT⁃proBNP and UA was significantly better than each index alone(P<0.05).Conclusion The serum CA125,NT⁃proBNP and UA levels are elevated in patients with CHF and AF,and they are significantly related to the prognosis of them.Combined detection of above three indexes has high evaluation value for their prognosis.
作者
崔泽岩
臧艳静
高淑娜
Cui Zeyan;Zang Yanjing;Gao Shuna(Department of Geriatrics,the NO.2 Hopsital of Baoding,Baoding 071000,China)
出处
《临床内科杂志》
CAS
2021年第2期97-100,共4页
Journal of Clinical Internal Medicine
基金
河北省保定市科技计划项目(1941ZF005)。
关键词
糖类抗原125
氨基末端脑钠肽前体
尿酸
慢性心力衰竭
心房颤动
预后
Carbohydrate antigen 125
N⁃terminal pro⁃brain natriuretic peptide
Uric acid
Chronic heart failure
Atrial fibrillation
Prognosis
