摘要
目的:探讨中枢神经细胞瘤(CN)的临床病理特点及鉴别诊断要点。方法:对2016年1月~2019年2月于弋矶山医院治疗的3例CN患者的临床病理资料进行回顾性分析,同时结合文献讨论其影像学特征、病理诊断、鉴别诊断、治疗与预后。结果:手术以肿瘤显微切除为主,3例肿瘤均位于脑室系统,光镜下瘤细胞内可见无核神经岛结构,1例可见菊形团。免疫组化染色显示肿瘤细胞会有神经元标记的蛋白神经元特异性烯醇化酶(NSE)和神经突触素(Syn)的阳性表达。3例患者随访11~44个月,均未见肿瘤复发或转移。结论:CN诊断需结合术前影像学及独特的病理学特征。主要与少突胶质细胞瘤、透明细胞型室管膜瘤、胚胎发育不良性神经上皮瘤相鉴别。肿瘤以外科手术切除为主,预后较好。
Objective:To investigate the clinicopathological features and differential diagnosis of central neurocytoma(CN).Methods:The clinical and pathological data were retrospectively analyzed in 3 cases of CN treated in Yijishan Hospital of Wannan Medical College between January 2016 and February 2019,and the related literatures were reviewed,with an attempt to identify the imaging features,pathological confirmation,differential diagnosis,treatment and prognosis of this condition.Results:The major treatment was dependent on microresection of the tumor.Of the 3 cases,tumor generally occurred in the ventricular system.Light microscopy exhibited nucleus-empty nerve island structure in the tumor cells,and 1 case of visible chrysanthemums.Immunohistochemical staining showed that tumor cells demonstrated positive expression of neuron-labeled proteins and neuron-specific enolase(NSE)and synaptophysin(Syn).The three patients were followed up for 11 to 44 months,and no tumor recurrence or metastasis was found.Conclusion:Diagnosis of CN needs to take preoperative imaging and unique pathological features into consideration,and should be distinguished from oligodendroglioma,clear cell ependymoma and embryonaldysplasia neuroepithelioma.Treatment of it primarily relies on radical surgical resection,and the prognosis appears better.
作者
刘雅玲
朱含梅
刘银华
李佳嘉
徐五琴
于涛
汪向明
LIU Yaling;ZHU Hanmei;LIU Yinhua;LI Jiajia;XU Wuqin;YU Tao;WANG Xiangming(Graduate School,Wannan Medical College,Wuhu 241002,China)
出处
《皖南医学院学报》
CAS
2021年第1期50-53,共4页
Journal of Wannan Medical College
基金
安徽省重点研究与开发计划项目(201904a07020034)。
