摘要
目的:基于系统评价和案例分析,探讨盐酸戊乙奎醚注射液引发视物模糊的临床特点及预后。方法:收集应急总医院上报的盐酸戊乙奎醚注射液引起视物模糊的病例,同时检索建库至2018年9月中国知网、万方数据库及中国生物医学文献数据库收录的关于盐酸戊乙奎醚注射液引起视物模糊的个案报告或临床研究。结果:(1)系统评价。纳入系统评价的临床研究文献共6篇(涉及患者710例),结果显示,戊乙奎醚致视物模糊发生率与东莨菪碱(OR=1.60,95%CI=0.75~3.39,P=0.22)、阿托品(OR=1.24,95%CI=0.58~2.67,P=0.58)的差异均无统计学意义。(2)案例分析。共纳入盐酸戊乙奎醚注射液引发视物模糊的病例10例,其中女性9例,男性1例;年龄8~82岁,其中青年人(18~40岁)最多(7例,占70%);盐酸戊乙奎醚注射液的用药目的,8例为麻醉前用药,2例用于解除胃肠道痉挛;盐酸戊乙奎醚注射液的给药剂量为0.3~2 mg,1例老年患者超量使用;盐酸戊乙奎醚注射液的给药方法为静脉注射和肌内注射;患者用药后表现为视近物模糊,自行好转,持续时间约16 h至7 d:10例患者的不良反应关联性评价结果均为“很可能”。结论:盐酸戊乙奎醚注射液引起视物模糊多发生于青年女性,其致视物模糊发生率与东莨菪碱、阿托品相当,临床表现为视近物模糊,持续时间约1周,无需特殊处理,可自行好转,预后良好。
OBJECTIVE:To probe into the clinical characteristics and prognosis of blurred vision induced by penehyclidine hydrochloride injection based on systematic review and clinical analysis.METHODS:The cases of blurred visual induced by penehyclidine hydrochloride injection in Emergency General Hospital was collected and retrieved by CNKI,Wanfang database and CBM until Sept.2018.RESULTS:(1)Systematic review.A total of 6 clinical studies were included in the systematic review(710 patients).There was no significant difference between the incidence of blurred vision induced by penehydramnios hydrochloride injection and scopolamine(OR=1.60,95%CI=0.75-3.39,P=0.22)and atropine(OR=1.24,95%CI=0.58-2.67,P=0.58).(2)Clinical analysis.A total of 10 cases of blurred vision induced by penehyclidine hydrochloride injection were included,including 9 females and 1 male,aged 8 to 82 years,of which young people(from 18 to 40 years)were the most(7 cases,70%).In terms of purpose of administration of penehyclidine hydrochloride injection,8 cases were treated before anesthesia and 2 cases were treated for gastrointestinal spasm relief.The dosage of penehyclidine hydrochloride injection was from 0.3 to 2 mg,which was overused in one elderly patient.The administration method of penehyclidine hydrochloride injection was intravenous injection and intramuscular injection.The patient showed blurred vision after taking penehyclidine hydrochloride injection and self-improvement,lasting for 16 h to 7 d:the evaluation results of the relevance of adverse drug reactions in 10 patients were“probable”.CONCLUSIONS:Blurred vision induced by penehyclidine hydrochloride injection mostly occurs in young women.The incidence of blurred vision induced by penehyclidine hydrochloride injection is similar to that of scopolamine and atropine,and the clinical manifestation is near-blurriness,lasting for 1 week,and no special treatment is needed,which can get better on its own with good prognosis.
作者
薛文鑫
李静
宗东江
孙劲文
王应利
李蕾
XUE Wenxin;LI Jing;ZONG Dongjiang;SUN Jinwen;WANG Yingli;LI Lei(Dept.of Pharmacy,Emergency General Hospital,Beijing 100028,China;Dept.of General Surgery and Oncology,Emergency General Hospital,Beijing 100028,China;Dept.of Ophthalmology,Emergency General Hospital,Beijing 100028,China;Dept.of Anesthesiology,Emergency General Hospital,Beijing 100028,China)
出处
《中国医院用药评价与分析》
2020年第12期1478-1482,共5页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
应急总医院医学发展科研基金(No.K201916)。
关键词
戊乙奎醚
视物模糊
不良反应
系统评价
Penehyclidine hydrochloride injection
Blurred vision
Adverse reactions
Systematic review
