摘要
The neurovascular unit(NVU)is an essential anatomical and physiological entity for the maintenance of brain homeostasis and function;it is composed of endothelial cells,pericytes,astrocytes,neurons,vascular smooth muscle cells,microglia,and oligodendroglia[1].The NVU regulates important brain vessel properties such as the integrity of the blood-brain barrier(BBB)and cerebral blood flow(CBF).Considerable efforts have been made to investigate the cerebral microcirculatory dysfunction in ageing and Alzheimer’s disease(AD)[2].
基金
the National Key R&D Program of China(2017YFC1307500 and 2017YFC1307504)
the National Natural Science Foundation of China(81925031,81972967 and 81820108026)
Science and Technology Program of Guangzhou Municipality,China(202007030001)。
