摘要
目的观察利伐沙班预防腹腔镜手术后深静脉血栓形成(DVT)的效果。方法选取60例普通外科患者作为研究对象,采用随机投掷法分为对照组和研究组,每组30例。对照组采用低分子肝素钠治疗,研究组采用利伐沙班治疗,比较2组DVT发生率和手术前后D-二聚体、纤维蛋白降解产物(FDP)、凝血指标[活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)和纤维蛋白原(FIB)]、组织型纤溶酶原激活剂(t-PA)、纤溶酶原激活抑制物-1(PAI-1)水平。结果术后,研究组DVT发生率低于对照组,但差异无统计学意义(P>0.05)。术前,2组D-二聚体、FDP水平比较,差异无统计学意义(P>0.05);术后,研究组D-二聚体、FDP水平低于对照组,差异有统计学意义(P<0.05)。术前,2组APTT、PT、FIB、t-PA、PAI-1水平比较,差异无统计学意义(P>0.05);术后24 h时,研究组APTT、PT、FIB、t-PA水平高于对照组,PAI-1水平低于对照组,差异有统计学意义(P<0.05)。结论利伐沙班可降低普通外科腹腔镜手术后DVT风险,改善患者凝血指标水平。
Objective To observe effect of rivaroxaban in preventing formation of deep venous thrombosis(DVT)after laparoscopic surgery.Methods A total of 60 patients in general surgery department were selected as research objects,and were divided into control group and study group according to random throwing method.The control group(n=30)was given low molecular weight heparin sodium treatment,and the study group(n=30)was given rivaroxaban.The incidence of DVT,D-dimer,fibrinogen degradation product(FDP),thrombin indexes[activated partial thromboplastin time(APTT),prothrombin time(PT)and fibrinogen(FIB)],tissue-type plasminogen activator(t-PA),plasminogen activator inhibitor-1(PAI-1)levels before and after surgery were compared.Results The incidence of DVT in the study group was lower than that in the control group,but there was no significant difference in comparison(P>0.05).There were no significant differences in the preoperative D-dimer level and FDP level between the two groups(P>0.05),D-dimer level and FDP level in the study group were significantly lower than those in the control group(P<0.05).There were no significant differences in the levels of APTT,PT,and FIB,t-PA and PAI-1 between the two groups before surgery(P>0.05).The APTT,PT,FIB and t-PA levels at 24 h after operation were significantly higher than those in the control group,and PAI-1 level was significantly lower than that in the control group(P>0.05).Conclusion Rivaroxaban can reduce the risk of DVT formation after laparoscopic surgery in general surgery department and improve coagulation indicators.
作者
韩博
任麦芳
王湘辉
董建新
王卫刚
HAN Bo;REN Maifang;WANG Xianghui;DONG Jianxin;WANG Weigang(Department of Digestive Surgery,Xi′an International Medical Center Hospital,Xi'an,Shaanxi,710100;Department of Oncology,Shaanxi Provincial Rehabilitation Hospital,Xi′an,Shaanxi,710065)
出处
《实用临床医药杂志》
CAS
2020年第24期88-91,共4页
Journal of Clinical Medicine in Practice
基金
陕西省自然科学基础研究计划项目(2019JQ-536)。
