摘要
目的凝血酶抗凝血酶复合物(TAT)和纤溶酶-α2抗纤溶酶复合物(PIC)均采用高敏化学发光法检测,具有灵.敏度高、检测速度快等优点。文中探讨TAT联合PIC诊断创伤患者相关弥散性血管内凝血(DIC)的临床价值。方法收集2018年5月至2019年12月解放军联勤保障部队908医院重症医学科收治的82例创伤患者临床资料。按照患者人院时创伤严重程度分为普通创伤组(n=63)和创伤性DIC组(n=19)。比较组间患者TAT及PIC水平;分析PIC、纤维蛋白降解产物(FDP)与D-二聚体水平的相关性。结果与普通创伤组患者TAT[21.7(10.6~47.6)ng/mL]和PIC[2.4(0.9~6.8)μg/mL]水平相比,创伤性DIC组的TAT[120.0(63.3~120.0)ng/mL]和PIC[7.0(4.8~10.0)μg/mL]均显著升高(P<0.05)。TAT与FDP和D-二聚体呈高度相关;PIC与FDP和D-二聚体均呈强相关,且TAT与DIC评分呈强相关。结论TAT≥42.3 ng/mL且PIC≥3.3g/mL可作为创伤性DIC更灵敏的诊断标准。
Objective To investigate the clinical value of thrombin-antithrombin complex(TAT)andα2-plasmin inhibitor-plasmin complex(PIC)in the diagnosis of disseminated intravascular coagulation(DIC)in trauma patients.Methods From May 2018 to December 2019,the clinical data of 82 trauma patients in the Department of critical medicine of the 908th Hospital of PLA were collected.The patients were divided into two groups:the general trauma group(n=63)and the traumatic DIC Group(n=19).The levels of TAT and PIC were compared and the correlation among PIC,FDP and DD were analyzed.Results Compared with the levels of TAT[21.7(10.6-47.6)ng/mL]and PIC[2.4(0.9-6.8)μg/mL]in the general trauma group,the levels of TAT[120.0(63.3-120.0)ng/mL]and PIC[7.0(4.8-10.0)μg/mL]in the traumatic DIC Group were significantly higher(P<0.05).TAT was highly correlated with FDP and DD,PIC was strongly correlated with FDP and DD,and TAT was strongly correlated with DIC score.Conclusion TAT≥42.3 ng/mL and PIC≥3.3μg/mL are more sensitive diagnostic criteria for traumatic DIC.
作者
胡艳晶
张益明
宋景春
张昕
林青伟
钟林翠
李兆芳
HU Yan-jing;ZHANG Yi-ming;SONG Jing-chun;ZHANG Xin;LIN Qing-wei;ZHONG lin-cui;LI Zhao-fang(Intensive Care Unit,908th Hospital of Chinese PLA Logistical Support Force,Nanchang 330002,Jiangxi,China)
出处
《医学研究生学报》
CAS
北大核心
2020年第12期1283-1287,共5页
Journal of Medical Postgraduates
基金
江西省卫健委科技计划(20204819)。
