摘要
糖尿病全球发病率逐渐升高,心血管疾病是其最主要的并发症之一。白细胞介素15是一种具有多种生物学活性的细胞因子,在减轻机体炎症、抗氧化应激、调节脂质代谢及改善胰岛素抵抗方面发挥重要作用。它还可明显减轻血管内皮细胞炎症反应,抑制动脉粥样硬化斑块形成,稳定斑块;改善心肌细胞能量代谢,减少心肌细胞损伤、凋亡,抑制心肌重构。文章对白细胞介素15在糖尿病并发心血管疾病中的研究进展进行综述,以期为糖尿病性心血管疾病的防治提供参考。
The global incidence rate of diabetes is increasing gradually, and cardiovascular disease is one of its major complications. Interleukin-15 is a cytokine with multiple biological activities, which plays an important role in reducing inflammation, antioxidant stress, regulating lipid metabolism and improving insulin resistance. It can also significantly reduce the inflammatory reaction of vascular endothelial cell, inhibit the formation of atherosclerotic plaque, stabilize plaque, improve myocardial cell energy metabolism, reduce myocardial cell injury and apoptosis, and inhibit myocardial remodeling. This article reviews the research progress of interleukin-15 in diabetes mellitus complicated with cardiovascular disease, in order to provide reference for the prevention and treatment of diabetic cardiovascular disease.
作者
李利霞
王皓
张守彦
LI Lixia;WANG Hao;ZHANG Shouyan(Department of Cardiology,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450000,China;Department of Cardiology,Luoyang Central Hospital Affiliated to Zhengzhou University&Luoyang Institute of Cardio-cerebrovascular Diseases&Luoyang Key Laborary of Cardiac-cerebro Tissue Injury and Repair,Luoyang,Henan 471009,China)
出处
《中国动脉硬化杂志》
CAS
2020年第12期1100-1104,共5页
Chinese Journal of Arteriosclerosis
基金
洛阳市科技计划医疗卫生项目(1820002A)。
