摘要
目的探讨EB病毒感染患儿的肝功能、免疫球蛋白、淋巴细胞亚群等实验室检查指标,为EB病毒感染引起的肝功能损害的诊治提供依据。方法收集2018年1月-2019年1月杭州市儿童医院收治的EB病毒感染患儿203例,203例患儿均开展了肝功能及血清免疫球蛋白的检测,其中有99例患儿进行了淋巴细胞亚群的分析,计量资料以中位数和四分位数[M(P25,P75)]表示,采用Mann-Whitney U检验。结果 EB病毒感染患儿的ALT、AST、GGT、ADA水平均高于正常体检儿童(P <0.05)。肝功能正常与肝功能异常组患儿的IGG、IGA、IGM、C3水平比较差异均有统计学意义(P <0.05),淋巴细胞亚群分析中发现2组的B淋巴细胞比较差异有统计学意义(P <0.05)。结论 EB病毒感染较易引起患儿的肝功能损害,肝损的发生可能与细胞免疫有关。
Objective To investigate the indexes of liver function,imm unoglobulin,lymphocyte subsets and other laboratory examinations in children infected with EBV.Methods A total of 203 patients with EBV infection admitted to Hangzhou Children’s Hospital from January 2018 to January 2019 were collected.203 patients were tested for liver function and serum immunoglobulin,and 99 of them were analyzed for lymphocyte subsets.Results The concentrations of ALT,AST,GGT and ADA in EBV infected children were all higher than those in normal children.The differences in IG G,IGA,IGM,and C3 between the two groups were statistically significant(P<0.05),and the comparison of B lymphocytes between the two groups was statistically significant in the analysis of lymphocyte subsets(P<0.05).Conclusion EBV infection is more likely to cause liver damage in child ren,and the occurrence of liver damage may be related to cellular immunity.
作者
叶萃英
赵昕峰
陈东
洪书迟
吴亦栋
YE Cui-ying;ZHAO Xin-feng;CHEN Dong;HONG Shu-chi;WU Yi-dong(Clinical Laboratory,Hangzhou Children’s Hospital,Hangzhou,Zhejiang 310014,China)
出处
《中国卫生检验杂志》
CAS
2020年第23期2898-2900,共3页
Chinese Journal of Health Laboratory Technology
