摘要
BACKGROUND Hepatitis E virus(HEV)superinfection is a suspected promoting factor for hepatocellular carcinoma(HCC)in patients with chronic hepatitis and cirrhosis.However,to date,very few cases of HEV-related HCC have been reported.Nevertheless,the role of HEV re-infection in cirrhotic liver without other chronic hepatitis infections has rarely been explored.CASE SUMMARY A 53-year-old male farmer was diagnosed with liver cirrhosis and splenomegaly in August 2016,accompanied with negative HEV-IgM and positive HEV-IgG.No evidence of hepatitis B virus or hepatitis C virus infection was found.Since then the patient was evaluated for liver function and viral parameters every 3 mo.In June 2017,the patient presented severe fatigue with whole body itching and was diagnosed with HCC.Afterwards this patient experienced quick HCC development,progression,relapse,and metastasis in the following 8 mo,and presented persistent dual positivity of HEV-IgM and HEV-IgG.This patient had a long history of smoking and alcohol consumption.CONCLUSION This unique case invokes the importance of HEV surveillance and treatment among cirrhotic patients,HCC cases,and blood donors.
