摘要
目的观察孕激素联合宫腔镜手术治疗子宫内膜样腺癌的临床疗效。方法选取2017年1月至2019年1月宝鸡市金台医院妇产科收治的60例子宫内膜样腺癌患者为研究对象。采用随机数表法分为观察组和对照组,每组30例。对照组采用宫腔镜手术治疗,观察组在此基础上联合孕激素治疗。随访1年记录两组患者的受孕和复发情况,并比较两组患者治疗前及治疗3个月后的糖类抗原125 (CA125)、癌胚抗原(CEA)、糖类抗原19-9(CA19-9)水平、癌症患者生存质量调查问卷(EORTC QLQ-C30)评分及不良反应发生情况。结果随访1年,观察组患者的受孕率为83.33%,明显高于对照组的53.33%,复发率为3.33%,明显低于对照组的23.33%,差异均有统计学意义(P<0.05);治疗后,观察组患者的CA125、CEA、CA19-9 [(23.19±3.18) IU/mL、(12.10±2.01) ng/mL、(32.19±4.46) IU/mL]明显低于对照组[(29.49±3.57) IU/mL、(16.27±1.99) ng/mL、(41.78±3.88) IU/mL],差异均有统计学意义(P<0.05);治疗后,观察组患者的躯体疼痛、物质生活、社会功能、生理职能评分[(71.12±4.22)分、(72.19±4.12)分、(71.69±3.88)分、(74.10±3.20)分]明显高于对照组[(65.19±4.12)分、(66.29±3.88)分、(63.28±4.90)分、(66.97±3.69)分],差异均有统计学意义(P<0.05);观察组患者的不良反应发生率为6.67%,明显低于对照组的30.00%,差异有统计学意义(P<0.05)。结论孕激素联合宫腔镜手术治疗子宫内膜样腺癌可降低肿瘤标志物水平,提高患者生存质量,减少不良反应,提高受孕率,减少复发,值得推广使用。
Objective To observe the clinical effect of progesterone combined with hysteroscopy in the treatment of endometrioid adenocarcinoma.Methods Sixty patients with endometrioid adenocarcinoma admitted to Department of Gynecology and Obstetrics,Jintai Hospital of Baoji City from January 2017 to January 2019 were selected as the research objects.Using random number table,the patients were divided into observation group and control group,with 30 patients in each group.The control group was treated by hysteroscopy,and observation group was treated with progesterone.The pregnancy and recurrence of the two groups were recorded after 1 year follow-up.The levels of carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9)levels,the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire(EORTC QLQ-C30),and adverse reactions were compared between the two groups before and after treatment for 3 months.Results After one year follow-up,the pregnancy rate of observation group was 83.33%,which was significantly higher than 53.33%of control group,and the recurrence rate was 3.33%,which was significantly lower than 23.33%of control group(P<0.05).After treatment,CA125,CEA,and CA19-9 in the observation group were(23.19±3.18)IU/mL,(12.10±2.01)ng/mL,(32.19±4.46)IU/mL,significantly lower than(29.49±3.57)IU/mL,(16.27±1.99)ng/mL,(41.78±3.88)IU/mL in the control group(P<0.05).After treatment,the scores of body pain,material life,social function,and physiological function of the observation group were(71.12±4.22)points,(72.19±4.12)points,(71.69±3.88)points,(74.10±3.20)points,significantly higher than(65.19±4.12)points,(66.29±3.88)points,(63.28±4.90)points,(66.97±3.69)points in the control group(P<0.05).The incidence of adverse reactions in observation group was 6.67%,which was significantly lower than 30.00%in control group(P<0.05).Conclusion Progesterone combined with hysteroscopic surgery in the treatment of endometrioid adenocarcinoma can reduce the level of tumor markers,improve the quality of life of patients,reduce adverse reactions,improve the pregnancy rate and reduce recurrence,which is worthy of promotion.
作者
张娟峰
杨晓婷
ZHANG Juan-feng;YANG Xiao-ting(Department of Obstetrics and Gynecology,Jintai Hospital of Baoji City,Baoji 721000,Shaanxi,CHINA;Department of Obstetrics and Gynecology,Maternal and Child Health Family Planning Service Center,Jintai District,Baoji City,Baoji 721001,Shaanxi,CHINA)
出处
《海南医学》
CAS
2020年第23期3085-3088,共4页
Hainan Medical Journal
关键词
子宫内膜样腺癌
孕激素
宫腔镜手术
生活质量
血清肿瘤标志物
不良反应
Endometrioid adenocarcinoma
Progesterone
Hysteroscopic surgery
Quality of life
Serum tumor markers
Adverse reactions
