摘要
目的观察子痫前期患者血清胎盘生长因子(PLGF)、人绒毛膜促性腺激素(β-HCG)水平变化,并探讨其临床意义。方法回顾性分析2017年5月至2019年5月间武警陕西省总队医院诊治的90例子痫前期患者的临床资料,其中48例重度子痫前期患者为重度组,42例轻度子痫前期患者为轻度组,择取60例正常妊娠的孕妇作为对照组,比较三组孕妇的血清PLGF、β-HCG水平。采用Logistic回归分析确定孕妇血清中的PLGF、β-HCG和子痫前期的关系,并采用受试者工作特征曲线(ROC)分析PLGF和β-HCG对重度子痫前期的诊断价值。结果轻度组、重度组和对照组孕妇血清PLGF水平分别为(72.15±20.17) pg/mL、(44.06±16.52) pg/mL、(92.04±28.64) pg/mL,β-HCG水平分别为(43 162.74±12 262.37) mlU/mL、(57 046.33±16 593.40) mlU/mL、(24 522.81±6 682.08) mlU/mL,重度组孕妇的PLGF水平明显低于轻度组和对照组,β-HCG水平明显高于轻度组和对照组,轻度组孕妇的PLGF水平明显低于对照组,β-HCG水平明显高于对照组,差异均有统计学意义(P<0.05);经非条件Logistic回归分析结果显示,孕妇血清中的PLGF和β-HCG是子痫前期的危险因素(P<0.05);PLGF联合β-HCG对重度子痫前期诊断的敏感性及特异性最高,曲线下面积(AUC)达0.893,敏感度及特异度分别为81.8%和87.5%。结论子痫前期患者血清PLGF、β-HCG水平存在显著异常,其检测有助于子痫前期患者病情严重程度的评估。
Objective To investigate the change and clinical significance of PLGF andβ-hCG in pregnant women with preeclampsia.Methods The clinical data of 90 patients with preeclampsia treated in Shaanxi Provincial General Hospital of Armed Police from May 2017 to May 2019 were retrospectively analyzed.The patients were divided into mild group(n=42)and severe group(n=48).At the same time,60 normal pregnant women were selected as the control group.The changes of serum PLGF andβ-hCG in three groups were analyzed.Non-conditional logistic regression analysis was used to determine the relationship between PlGF,β-hCG,and preeclampsia,and receiver operating characteristic curve(ROC)was used to analyze the diagnostic value of PLGF andβ-hCG in severe preeclampsia.Results The levels of PLGF in mild group,severe group,and control group were(72.15±20.17)pg/mL,(44.06±16.52)pg/mL,(92.04±28.64)pg/mL,respectively,and the levels ofβ-hCG were(43162.74±12262.37)mlU/mL,(57046.33±16593.40)mlU/mL,(24522.81±6682.08)mlU/mL,respectively.PLGF in severe group was significantly lower than that in mild group and control group,andβ-hCG was significantly higher than that in mild group and control group,with statistically significant difference(P<0.05).PLGF in mild group were significantly lower than that in control group,andβ-hCG in mild group were significantly lower than that in control group(P<0.05).According to the analysis of unconditional logistic regression,PLGF andβ-hCG in maternal serum are risk factors of preeclampsia and severe preeclampsia.The sensitivity and specificity of PLGF combined withβ-hCG were the highest,and area under curve(AUC),sensitivity,and specificity were 0.893,81.8%,and 87.5%,respectively.Conclusion The levels of PLGF andβ-hCG are related to the development of preeclampsia.The detection of these two factors is helpful for the diagnosis and evaluation of preeclampsia.
作者
姚守润
崔海斌
孔令丹
YAO Shou-run;CUI Hai-bin;KONG Ling-dan(Medical Service Department,Shaanxi Provincial General Hospital of Armed Police,Xi'an 710054,Shaanxi,CHINA;Department of Obstetrics and Gynecology,Beijing Sixth Hospital,Beijing 100010,CHINA)
出处
《海南医学》
CAS
2020年第23期3078-3080,共3页
Hainan Medical Journal
关键词
子痫前期
胎盘生长因子
人绒毛膜促性腺激素
妊娠
孕妇
危险因素
Preeclampsia
Placental growth factor
Human chorionic gonadotropin
Pregnancy
Pregnant women
Risk factors
