摘要
眼眶淋巴瘤是常见的眼附属器恶性肿瘤,主要由B淋巴细胞来源的黏膜相关性淋巴组织的结外边缘区B细胞淋巴瘤(EMZL)、滤泡性淋巴瘤(FL)、弥漫性大B细胞淋巴瘤(DLBCL)、套细胞淋巴瘤(MCL)及较少见的T淋巴细胞来源的自然杀伤性T细胞淋巴瘤(NK-TL)和外周T细胞淋巴瘤(PTCL)等组成。眼眶淋巴瘤的流行病学分布存在一定特点,绝大多数眼眶淋巴瘤起源于B淋巴细胞,其中EMZL是较常见的亚型,其次是DLBCL、FL和MCL。眼眶淋巴瘤主要发病人群为老年人;并且淋巴瘤亚型的分布与性别有关,EMZL和FL均好发于女性,MCL则更倾向于男性。本文主要对近年来眼眶淋巴瘤的流行病学研究进展进行总结,期望为眼眶淋巴瘤病因及发病机制的研究、疾病临床诊断及防治措施的制定提供参考。
Orbital lymphoma,mainly composed of B-lymphocytes lymphoma and rare T-lymphocytes lymphoma,is the most frequent malignancy of the ocular adnexa.Orbital lymphoma is normally classified into different subtypes according to the origin of lymphocytes.For instance,extranodal marginal zone B-cell lymphoma(EMZL),diffuse large B-cell lymphoma(DLBCL),follicular lymphoma(FL)and mantle cell lymphoma(MCL)stem from B-lymphocytes while natural killer T-cell lymphoma(NK-TL)and peripheral T-cell lymphoma(PTCL)come from T-lymphocytes.The epidemiological distribution of orbital lymphoma has certain characteristics.For example,the majority of orbital lymphomas originate from B-lymphocytes,among which EMZL is the most common subtype,followed by DLBCL,FL and MCL.In the meantime,orbital lymphoma primarily occurs in the elderly.The distribution of gender varies according to the disparate subtypes of orbital lymphomas.A female predominance is found among patients with EMZL and FL,while MCL tends to occurr in male.In this paper,the progress of epidemiological research of orbital lymphoma published in recent years was summarized,so as to provide new thoughts for the study of the etiology and pathogenesis of orbital lymphoma,as well as the clinical diagnosis and treatment of the orbital lymphoma.
作者
孙梅(综述)
马建民(审校)
Sun Mei;Ma Jianmin(Beijing Tongren Hospital,Capital Medical University,Beijing Tongren Eye Center,Beijing Institute of Ophthalmology,Beijing Ophthalmology&Vision Science Key Lab,Beijing 100730,China)
出处
《中华实验眼科杂志》
CAS
CSCD
北大核心
2020年第11期979-982,共4页
Chinese Journal Of Experimental Ophthalmology
基金
国家自然科学基金项目(81371052)
北京市自然科学基金项目(7182038)。
