摘要
目的研究盐酸米诺环素软膏治疗慢性牙周炎的效果和安全性。方法选择2016年6月—2019年6月本院收治的86例慢性牙周炎患者作为研究对象,按照随机数表法分为观察组和对照组两组,每组各43例。所有患者均接受牙周基础治疗,其中对照组应用复方碘甘油治疗,观察组应用盐酸米诺环素软膏治疗。将两组的炎性因子指标、牙周指标、临床疗效、不良反应发生情况进行比对。结果观察组患者治疗后的炎性因子水平、牙周指标数据均低于对照组,差异具有统计学意义(P<0.05);观察组患者的临床总有效率高于对照组,不良反应发生率低于对照组,差异具有统计学意义(P<0.05)。结论盐酸米诺环素软膏应用在慢性牙周炎患者治疗中具有较高的有效性和安全性,能够有效减轻炎症反应和改善牙周参数,适合在临床中推广应用。
Objective To study the efficacy and safety of minocycline hydrochloride ointment in the treatment of chronic periodontitis.Methods From June 2016 to June 2019,86 patients with chronic periodontitis those admitted to our hospital were included in the study.They were divided into two groups according to the method of random number table.They all received basic periodontal treatment,43 cases in the control group were treated with compound iodine glycerin,43 cases in the observation group were treated with minocycline hydrochloride ointment.The inflammatory factor index,periodontal index,clinical effect and adverse reactions of the two groups were compared.Results The level of inflammatory factors and periodontal index data in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The total clinical effective rate of the observation group was higher than that in the control group,and the incidence of adverse reactions was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusions Minocycline hydrochloride ointment has high efficacy and safety in the treatment of chronic periodontitis,it could effectively reduce inflammatory reaction and improve periodontal parameters,and is suitable for clinical application.
作者
黄志耿
HUANG Zhi-geng(Department of Stomatology,people's hospital Chaoyang district,Shantou,Guangdong,515100,China)
出处
《齐齐哈尔医学院学报》
2020年第17期2196-2198,共3页
Journal of Qiqihar Medical University
关键词
慢性牙周炎
盐酸米诺环素软膏
炎性因子
安全性
Chronic periodontitis
Minocycline hydrochloride ointment
Inflammatory factors
Safety
