摘要
目的探讨婴儿发生牛奶蛋白过敏的影响因素,为减少婴儿牛奶蛋白过敏提供参考。方法疑似牛奶蛋白过敏婴儿112例,根据牛奶蛋白回避试验及开放性牛奶蛋白激发试验结果分为过敏组61例和正常组51例。比较2组临床资料,血清三酰甘油、总胆固醇、前白蛋白水平及父母食物过敏、母亲孕期使用抗生素情况;多因素logistic回归分析牛奶蛋白过敏发生的影响因素。结果过敏组血清三酰甘油[(0.51±0.03)mmol/L]、总胆固醇[(2.44±0.25)mmol/L]、前白蛋白[(103.67±9.85)mg/L]水平低于正常组[(1.01±0.12)mmol/L、(4.71±0.58)mmol/L、(246.34±15.87)mg/L](P<0.05),父母食物过敏比率(81.97%)、母亲孕期使用抗生素比率(27.87%)高于正常组(58.82%、11.76%)(P<0.05);2组喂养方式、添加辅食时间比较差异均有统计学意义(P<0.05),年龄、性别比例、胎龄、出生时体长、分娩方式等比较差异均无统计学意义(P>0.05)。多因素logistic回归分析结果显示,父母食物过敏(OR=2.837,95%CI:1.231~7.645,P=0.027)、母亲孕期使用抗生素(OR=2.932,95%CI:1.317~8.652,P=0.028)、喂养方式(OR=1.292,95%CI:1.074~5.348,P=0.045)、添加辅食时间(OR=2.874,95%CI:1.184~8.457,P=0.029)是婴儿发生牛奶蛋白过敏的影响因素。结论婴儿牛奶蛋白过敏与母亲孕期期间服用抗生素、父母食物过敏以及添加辅食时间有关。
Objective To investigate the influencing factors for cow’s milk protein allergy(CMPA) in infants and to provide reference for preventing CMPA. Methods Totally 112 infants with suspected CMPA were divided into allergy group(n=61) and normal group(n=51) according to the results of milk protein avoidance test and open milk protein challenge test. The clinical data, serum triacylglycerol, total cholesterol, prealbumin, parental food allergies and mother’s use of antibiotics during pregnancy were compared between two groups. Multivariate logistic regression analysis was used to analyze the influencing factors for CMPA. Results The levels of triacylglycerol, total cholesterol and prealbumin were lower in allergy group((0.51±0.03) mmol/L,(2.44±0.25) mmol/L,(103.67±9.85) mg/L) than those in normal group((1.01±0.12) mmol/L,(4.71±0.58) mmol/L,(246.34±15.87) mg/L)(P<0.05), while the percentages of parental food allergies and mothers’ use of antibiotics during pregnancy were higher in allergy group(81.97%, 27.87%) than those in normal group(58.82%, 11.76%)(P<0.05). There were significant differences in the feeding method and the time of adding supplementary food between two groups(P<0.05), and no significant differences in the age, gender ratio, gestational age, height at birth and delivery mode between two groups(P>0.05). Multivariate logistic regression analysis showed that parental food allergies(OR=2.837, 95%CI: 1.231-7.645, P=0.027), mothers’ use of antibiotics during pregnancy(OR=2.932, 95%CI: 1.317-8.652, P=0.028), feeding methods(OR=1.292, 95%CI: 1.074-5.348, P=0.045) and time of adding supplementary food(OR=2.874, 95%CI:1.184-8.457, P=0.029) were the influencing factors for CMPA. Conclusion CMPA is correlated with mothers’ use of antibiotics during pregnancy, parental food allergies and the time of adding supplementary food.
作者
李永春
李小芹
于志丹
王菊平
LI Yongchun;LI Xiaoqin;YU Zhidan;WANG Juping(Department of Gastroenterology,Children's Hospital Affiliated to Zhengzhou University,Henan Children's Hospital Zhengzhou Children's Hospital,Zhengzhou 450000,China;Department of Pharmacy,Children's Hospital Affiliated to Zhengzhou University,Henan Children's Hospital Zhengzhou Children's Hospital,Zhengzhou 450000,China)
出处
《中华实用诊断与治疗杂志》
2020年第11期1096-1098,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
国家自然科学基金青年科学基金(81903330)。
关键词
牛奶蛋白过敏
婴儿
影响因素
cow’s milk protein allergy
infants
influencing factors
