摘要
目的探讨血清降钙素原(PCT)、C-反应蛋白(CRP)及神经元特异性烯醇化酶(NSE)检测在小儿感染性脑膜炎诊疗过程中的应用价值。方法选取49例急性化脓性脑膜炎患儿为化脓性组,65例病毒性脑膜炎患儿为病毒性组,50例健康儿童为对照组,观察不同感染类型脑膜炎患儿临床表现,比较3组受试儿童血清PCT、CRP及NSE水平差异,分析不同时期脑膜炎患儿PCT、CRP及NSE变化。结果2种感染类型脑膜炎患儿临床表现以发热、精神萎靡、意识障碍、呕吐、抽搐以及脑膜刺激征为主,其中化脓性组精神萎靡、意识障碍、脑膜刺激征等发生率显著高于病毒性组,差异有统计学意义(P<0.05)。化脓性组和病毒性组血清PCT、CRP及NSE浓度及异常率均显著高于对照组,差异有统计学意义(P<0.05),其中化脓性组血清PCT、CRP水平及异常率显著高于病毒性组,血清NSE浓度及异常率低于病毒性组,差异均有统计学意义(P<0.05)。恢复期,化脓性组和病毒性组血清PCT、CRP及NSE浓度均显著降低,而化脓性组血清PCT、CRP浓度仍高于病毒性组,NSE浓度低于病毒性组,差异均有统计学意义(P<0.05)。结论PCT、CRP及NSE参与脑膜炎的病理过程,通过检测血清PCT、CRP及NSE有助于脑膜炎的临床诊断和判断感染类型。
Objective To investigate the application value of the detection of serum levels of procalcitonin(PCT),C reactive protein(CRP)and neuron specific enolase(NSE)in diagnosis and treatment of acute meningitis in chidren.Methods A total of 49 children with acute purulent meningitis were enrolled as purulent meningitis group,and the other 65 children with viral meningitis were enrolled as viral meningitis group,moreover,the 50 healthy children wee enrolled as control group.The clinical manifestations of different infection type meningitis,and the changes of serum levels of PCT,CRP and NSE were observed and compared among the three groups.Results The clinical manifestations in the two kinds of meningitis groups were mainly fever,mental malaise,consciousness disturbance,vomiting,convulsion and meningeal stimulation signs.The incidence rates of mental malaise,consciousness disturbance and meningeal stimulation signs in urulent meningitis group were significantly higher than those in viral meningitis group(P<0.05).The abnormal rate and serum levels of PCT,CRP and NSE in both meningitis groups were significantly higher than those in control group(P<0.05).Moreover the abnormal rate and serum levels of PCT,CRP in urulent meningitis group were significantly higher than those in viral meningitis group(P<0.05),however,the abnormal rate and serum levels of NSE in urulent meningitis group were significantly lower than those in viral meningitis group(P<0.05).In addition the serum levels of PCT,CRP and NSE in both meningitis group were significantly decreased at recovery period(P<0.05),and the serum levels of PCT,CRP in urulent meningitis group were significantly higher than those in viral meningitis group(P<0.05),however,the serum levels of of NSE in urulent meningitis group were significantly lower than those in viral meningitis group(P<0.05).Conclusion PCT,CRP and NSE are involved in the pathological process of meningitis.The detection of serum levels of PCT,CRP and NSE is helpful for clinical diagnosis and diagnosis of meningitis.
作者
贺巧峰
苏乐
吴婷婷
HE Qiaofeng;SU Le;WU Tingting(Department of Pediatrics,The First Hospital of Yulin City,Shaanxi,Yulin 719000,China)
出处
《河北医药》
CAS
2020年第22期3428-3430,3434,共4页
Hebei Medical Journal
