摘要
人类免疫缺陷病毒(humanimmunodeficiencyvirus,HIV)感染孕妇应尽早使用联合抗病毒治疗阻断HIV母婴传播,抗病毒治疗时间越早、越长,阻断效果越明显。但在临床上常见部分HIV感染孕妇直到妊娠晚期或临产前才来就诊,对这部分患者在保证安全的前提下,如何进行抗病毒治疗快速阻断HIV母婴传播,在选择药物时,除了考虑快速强效抑制病毒,还要注意药物对胎儿的安全性、脐带血药物浓度及新生儿药物洗脱等问题。本文就国内外孕妇感染HIV的现状、HIV母婴阻断用药现状及妊娠晚期HIV母婴阻断常用ARV药物等问题进行讨论。
According to the domestic and foreign guidelines,combining antiretrovinal treatment was recommended for the HIV-infected pregnant women to prevent mother to child transmission(PMTCT).As the earlier and longer antiviral treatment,the efetst of blocking were more obviously.However,in fact,sevenal HIV-infected pregnant women did not come to hospital unpil the third trimester of pregnancy or before childbirth.Rapid inhibition of virus,the safety of fetuses,drug concentration in cord blood and neonatal drug elution were crucial for these patients to PMTCT of HIV.We discussed the status of pregnant women with HIV infection in the world,drugs for PMTCT of HIV and the usage of ARV drugs in late trimester,and 80 on.
出处
《中华产科急救电子杂志》
2020年第4期195-198,共4页
Chinese Journal of Obstetric Emergency（Electronic Edition）
基金
“十三五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项艾滋病综合治疗方案的优化及推广应用研究(2017ZX10202101-003-001)
2018年度艾滋病和病毒性肝炎等重大传染病防治科技重大专项艾滋病精准诊治标志物的鉴定(2018ZX10302103)
广州市科技计划项目艾滋病功能性治愈新策略-临床与基础研究(201803040002)。
关键词
HIV感染
妊娠晚期
治疗
抗病毒
传染性疾病传播
垂直
HIV infection
Third trimester of pregnancy
Therapy,antiviral
Infectious disease transmission,vertical
