摘要
胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)的减少在肥胖和2型糖尿病(type 2 diabetes mellitus,T2DM)中的重要作用为运动降低体重和血糖、改善胰岛素敏感性,以及防治肥胖及T2DM的机制研究提供了一个新视角。近年来的研究发现,运动可能通过谷氨酰胺(glutamine,Gln)、白介素-6(interleukin-6,IL-6)、游离脂肪酸(free fatty acid,FFA)、交感-肾上腺髓质系统介导GLP-1的增加。增加的GLP-1可发挥改善胰岛β细胞功能,促进β细胞增殖、抑制β细胞凋亡、抑制食欲和胃排空以及降低chemerin等作用,从而提高胰岛素敏感性、减少能量摄入和改善血糖水平。这可能是运动防治肥胖、T2DM的机制之一,但仍需更多研究证实。该文就运动增加肥胖和2型糖尿病患者体内GLP-1水平的作用、机制及其生物学意义做一综述。
The important role of decreased glucagon-like peptide-1(GLP-1)in obesity and type 2 diabetes mellitus(T2DM)provides a new perspective for the mechanisms of exercise-induced reductions of weight and plasma glucose,improvement of insulin sensitivity,as well as prevention and treatment of obesity and T2DM.Recent studies have found that exercise induced the increase of GLP-1 through the mediation of glutamine(Gln),interleukin-6(IL-6),free fatty acids(FFA),and the sympathetic-adrenal medulla system.The increased GLP-1 resulted in the improved function of isletβcell,pro-proliferation and anti-apoptosis ofβcell,suppressed appetite,inhibited gastric emptying and reduced chemerin,thus increasing insulin sensitivity,reducing energy intake and plasma glucose levels.This may be one of the mechanisms of exercise-mediated preventing and treating obesity and T2DM,but needs to be further confirmed.This article summarized the role of exercise-induced increase of GLP-1 in obesity and T2DM and its significance and mechanism.
作者
张奇龙
王晓慧
ZHANG Qi-Long;WANG Xiao-Hui(School of Kinesiology,Shanghai University of Sport,Shanghai 200438,China)
出处
《生命科学》
CSCD
北大核心
2020年第9期963-971,共9页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(31872801)
上海市人类运动能力开发与保障重点实验室(上海体育学院)(11DZ2261100)。
