摘要
目的分析缺血性脑卒中伴脑微出血(CMBs)与2型糖尿病及糖化血红蛋白(HbA1c)的相关性。方法回顾性分析2018年6月-2019年4月本院收治的82例急性脑卒中患者的临床资料,根据是否伴有糖尿病分为无糖尿病组36例,糖尿病组46例。收集2组临床资料,比较2组CMBs数量及HbA1c水平,并进行相关性分析。结果糖尿病组HbA1c水平高于无糖尿病组(P<0.05),糖尿病组入院时存在CMBs例数及CMBs数量多于无糖尿病组(P<0.05);糖尿病组发病90 d时CMBs增加数量多于无糖尿病组(P<0.05)。存在脑卒中史、高胆固醇血症、2型糖尿病和HbA1c>6%是影响发病90 d时CMBs增加的独立危险因素(P<0.05)。结论2型糖尿病患者CMBs发生率显著升高,可作为急性缺血性脑卒中伴CMBs的独立危险因素,重视HbA1c水平的变化对监测急性缺血性脑卒中伴CMBs的病情变化有重要意义。
Objective To analyze the correlation of ischemic stroke with cerebral microbleeds(CMBs)with type 2 diabetes mellitus(T2DM)and glycated hemoglobin(HbA1c).Methods The clinical data of 82 patients with acute stroke admitted to our hospital from April 2017 to April 2019 were analyzed,and they were divided into a non-T2DM group(n=36)and a T2DM group(n=46)according to presence or absence of T2DM.The clinical data of each group were collected,the number of cerebral microbleeds and the level of HbA1c of patients in each group were compared,and the correlation was analyzed.Results The level of HbA1c in T2DM group was higher than that in the non-T2DM group(P<0.05).The number of patients with CMBs and the number of CMBs on admission were more than those in T2DM group(P<0.05).The number of patients with CMBs on the 90th day in T2DM group was more than that in non-T2DM group(P<0.05).Presence of stroke history,high cholesterol concentration,T2DM and HbA1c>6%were the independent risk factors that lead to an increase in CMBs on the 90th day(P<0.05).Conclusion The incidence of cerebral microbleeds in patients with T2DM was significantly increased,which can be used as an independent risk factor for acute ischemic stroke(AIS)with CMBs.Focusing on the changes in the level of HbA1c is of great significance in monitoring the changes of AIS with CMBs.
作者
徐金静
靳玉娟
吕静静
XU Jin-jing;JIN Yu-juan;LYU Jing-jing(Department of Neurology,Yanda Hospital,Langfang,Hebei 065201,China)
出处
《解放军医药杂志》
CAS
2020年第11期80-83,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
河北廊坊市科技局(2018013008)。
关键词
急性缺血性脑卒中
脑出血
糖尿病
2型
糖化血红蛋白
高胆固醇血症
Acute ischemic stroke
Cerebral hemorrhage
Diabetes mellitus,type 2
Glycated hemoglobin
Hypercholesterolemia
