摘要
目的探讨血管紧张素-(1-7)[angiotensin(1-7),Ang-(1-7)]、血管紧张素转换酶2(angiotensin-converting enzyme 2,ACE2)、Mas与子宫内膜癌患者临床和病理特征的关系。方法回顾性分析行子宫内膜癌切除手术的子宫内膜癌120例的临床资料,比较子宫内膜癌与癌旁正常组织中Ang-(1-7)、ACE2和Mas表达情况,并分析子宫内膜癌组织Ang-(1-7)、ACE2和Mas表达与子宫内膜癌患者临床和病理特征的关系。结果子宫内膜癌组织中Ang-(1-7)和ACE2阳性表达率显著低于癌旁正常组织,Mas阳性表达率显著高于癌旁正常组织,差异有统计学意义(P<0.01)。临床分期为Ⅰ或Ⅱ期、病理分期为G1期、浸润深度<浅肌层、无淋巴结转移的子宫内膜癌患者子宫内膜癌组织Ang-(1-7)和ACE2阳性表达率显著高于临床分期为Ⅲ或Ⅳ期、病理分期为G2或G3期、浸润深度≥浅肌层、有淋巴结转移的子宫内膜癌患者;临床分期为Ⅰ或Ⅱ期、病理分期为G1期、浸润深度<浅肌层、无淋巴结转移的子宫内膜癌患者子宫内膜癌组织Mas阳性表达率显著低于临床分期为Ⅲ或Ⅳ期、病理分期为G2或G3期、浸润深度≥浅肌层、有淋巴结转移的子宫内膜癌患者,差异均有统计学意义(P<0.05或P<0.01)。结论子宫内膜癌组织中Ang-(1-7)、ACE2和Mas表达异常与肿瘤临床分期、病理分期、浸润深度、淋巴结转移密切相关。
Objective To explore the relationship between angiotensin(1-7)[angiotensin(1-7),Ang-(1-7)],angiotensin-converting enzyme 2(ACE2),Mas and clinicopathological characteristics of patients with endometrial cancer.Methods The clinical data of 120 cases of endometrial cancer undergoing endometrial cancer resection were retrospectively analyzed.The expression of Ang-(1-7),ACE2 and Mas in endometrial cancer and adjacent normal tissues was compared,and the relationship between the expression of Ang-(1-7),ACE2 and Mas in endometrial cancer tissues and the clinicopathological characteristics of patients with endometrial cancer was analyzed.Results The positive expression rate of Ang-(1-7)and ACE2 in endometrial cancer tissues was significantly lower than that of adjacent normal tissues,and the positive rate of Mas was significantly higher than adjacent normal tissues(P<0.01).The positive expression rate of Ang-(1-7)and ACE2 in endometrial cancer patients with clinical stageⅠorⅡ,pathological grade G1,infiltration depth<superficial muscle layer,and no lymph node metastasis was significantly higher than that of clinical stageⅢor IV,pathological grade G2 or G3,depth of invasion≥superficial muscle layer,and lymph node metastasis.The Mas positive expression rate in endometrial cancer patients with clinical stage of stage I or II,pathological grade G1,depth of invasion<superficial muscle layer,and no lymph node metastasis was significantly lower than that of endometrial cancer patients with clinical stage III or IV,pathological grade G2 or G3,invasion depth≥superficial muscle layer,and lymph node metastasis(P<0.05 or P<0.01).Conclusion Abnormal expression of Ang-(1-7),ACE2 and Mas in endometrial cancer tissue is closely related to the clinical stage,pathological grade,depth of invasion,and lymph node metastasis.
作者
陈丽华
朱婕曼
刘玉凤
刘浩
马春星
张凡
刘云春
CHEN Li-hua;ZHU Jie-man;LIU Yu-feng;LIU Hao;MA Chun-xing;ZHANG Fan;LIU Yun-chun(Department of Obstetrics and Gynecology,the First Hospital Affiliated to Hebei North University,Zhangjiakou,Hebei 075000,China;Department of Pathology,the First Hospital Affiliated to Hebei North University,Zhangjiakou,Hebei 075000,China)
出处
《临床误诊误治》
2020年第11期85-90,共6页
Clinical Misdiagnosis & Mistherapy
基金
河北省医学科学研究重点课题计划(20180836)。
