摘要
目的探讨子宫内膜癌患者的生存情况及其与临床病理特征及癌组织中雌激素受体(ER)、孕激素受体(PR)、细胞增殖抗原Ki-67、肿瘤抑制基因P53表达的相关性。方法选取接受手术治疗的409例子宫内膜癌患者作为研究对象,计算术后1年、3年、5年生存率。分析患者的生存状况与临床病理特征和癌组织中ER、PR、Ki-67、P53表达的相关性。结果409例子宫内膜癌患者术后1年、3年、5年生存率分别为98.0%、92.0%和83.0%。病理类型、组织分化程度、淋巴结转移情况、癌组织中PR和P53表达情况是子宫内膜癌患者生存的独立影响因素(均P<0.05)。结论非子宫内膜样腺癌、组织学分级低、有淋巴结转移、癌组织PR阴性或P53阳性的子宫内膜癌患者生存预后差,ER、Ki-67的表达情况与患者预后的关系有待进一步研究。
Objective To explore the survival rate and its correlation with clinicopathological characteristics,and the expression of carcinoma tissue estrogen receptor(ER),progesterone receptor(PR),proliferation cell nuclear antigen Ki-67,and tumor suppressor gene P53 in patients with endometrial carcinoma(EC).Methods A total of 409 EC patients who received surgical treatment were selected as study subjects,and their postoperative 1-,3-and 5-year survival rates were calculated.The correlations of survival rate with clinicopathological characteristics and the expression of ER,PR,Ki-67 or P53 in carcinoma tissues were analyzed in the patients.Results Among the 409 EC patients,the postoperative 1-,3-and 5-year survival rates were 98.0%,92.0%and 83.0%,respectively.Pathological type,degree of tissue differentiation,lymph node metastasis,and expression of PR and P53 in carcinoma tissues were the independent influencing factors of survival rate of EC patients(all P<0.05).Conclusion Poor prognosis regarding survival is seen in EC patients with non endometrioid adenocarcinoma,low histological grade,lymph node metastasis,carcinoma tissue PR negative or P53 positive.Further research on the relationship of ER or Ki-67 expression with prognosis should be performed in the patients.
作者
练梦南
韦有生
姚德生
LIAN Meng-nan;WEI You-sheng;YAO De-sheng(Department of Gynecology,the Eighth People′s Hospital of Nanning,Nanning 530001,China;Department of Gynecological Tumor,Guangxi Medical University Affiliated Tumor Hospital,Nanning 530021,China)
出处
《广西医学》
CAS
2020年第19期2518-2523,2529,共7页
Guangxi Medical Journal
