摘要
钛及钛合金因良好的生物相容性和机械性能已成为目前人工种植体最主要材料,但其自身的惰性和缺乏生物活性的缺点会影响种植体骨结合效能,进而影响种植体的长期稳定性。为解决这一难题,学者们尝试采用生物化学法对钛及钛合金种植体表面进行改性,赋予种植体表面生物活性来提高种植体骨结合率。生物化学改性是将生物活性分子包括细胞外基质蛋白、生长因子及生物活性小分子如多肽等通过物理、化学方式结合于生物惰性钛或钛合金人工种植体表面,诱导种植床成骨细胞粘附、增殖、分化成骨,促进种植体骨结合。本文就该领域近年来研究较多的、用于种植体表面生物化学改性的方法、主要的生物活性蛋白和多肽的研究和应用进展进行综述。
Titanium and titanium alloys have become the most important materials for artificial implants due to good biocompatibility and mechanical properties,but lacking biological activity may affect the osseointegration efficiency and the long-term stability of the implants.To solve this problem,scholars have tried to use biochemical methods to modify the surface of titanium and titanium alloy implants which could impart biological activity to the surface of the implants and improve the osseointegration.Biochemical modification is to combine bioactive molecules,including extracellular matrix proteins,growth factors,and bioactive small molecules such as polypeptides,on the surface of titanium or titanium alloy implants with physical and chemical methods.And biochemical modification aims to induce osteoblasts to attach to the implant surface,proliferate and differentiate into bone tissue,and finally promote osseointegration of implants.This article summarizes the methods of biochemical modification,the main bioactive proteins and peptides that have been applied on implant surface in this field in recent years.
作者
崔建通
贺慧霞
CUI Jian-tong;HE Hui-xia(First Clinical Medical Center of PLA General Hospital,Beijing 100853,China)
出处
《口腔颌面修复学杂志》
2020年第4期251-256,共6页
Chinese Journal of Prosthodontics
基金
国家高科技研究发展(863)计划(项目编号:2015AA033502)。
关键词
种植体
骨结合
生物活性因子
生物化学改性
implant
osseointegration
bioactive factor
biochemical modification
