摘要
目的探讨胃底腺黏膜型腺癌的临床病理学特征及免疫组化表型。方法总结山东省立医院西院病理科确诊的1例胃底腺黏膜型腺癌的临床及病理学资料,分析其组织形态学特点及免疫组织化学染色表达,并复习相关文献。结果老年女性,胃底大弯侧见直径2.0 cm的不规则表浅隆起,中央浅糜烂,行内镜下黏膜剥脱术,肿瘤组织镜下为中-高分化管状腺癌,伴有乳头状腺癌,免疫组化染色小凹上皮分化区域MUC5AC(+);胃底腺分化区域MUC6(+)、pepsinogen-I(+);Ki-67指数约5%。结论胃底腺黏膜型腺癌是一种新的肿瘤类型,发病率极低,既有胃底腺型腺癌的内镜和病理特征,又有小凹上皮来源腺癌的内镜和病理特征;加强该肿瘤的认识有助于对其正确诊断与治疗。
Objective To explore the clinicopathological characteristics and immunohistochemical phenotypes of gastric adenocarcinoma of fundic gland mucosa type.Methods The clinical data,pathologic characteristics and immunohistochemical expression characteristics of one case of gastric adenocarcinoma of fundic gland mucosa type confirmed by Department of Pathology of Shandong Provincial Western Hospital were collected and analyzed,and related literatures were reviewed.Results An elderly women,with irregular superficial bulges of 2.0 cm in diameter on the greater curvature of the stomach fundus,superficial erosions in the center,underwent endoscopic submucosal dissection,tumor histologically showed moderate to well-differentiated tubular adenocarcinoma with papillary adenocarcinoma,immunohistochemistry showed MUC5AC(+)in foveal epithelial differentiation area,MUC6(+)and pepsinogen-Ⅰ(+)in gastric fundus gland differentiation area,and Ki-67 index was about 5%.Conclusion Gastric adenocarcinoma of fundic gland mucosa type is a new type of tumor with a very low incidence.It has the endoscopic and pathological features of both gastric fundus adenocarcinoma and small concave epithelial-derived adenocarcinoma.Enhancing understanding of this tumor is helpful for correct diagnosis and treatment.
作者
张丽华
王硕
李义
刘倩
Zhang Lihua;Wang Shuo;Li Yi;Liu Qian(Department of Pathology,the 960th Hospital of the PLA,Jinan 250031,China;Department of Pathology,Shandong Provincial Western Hospital,Jinan 250022,China;Department of Gastroenterology,Shandong Provincial Western Hospital,Jinan 250022,China)
出处
《中华消化病与影像杂志（电子版）》
2020年第6期279-282,共4页
Chinese Journal of Digestion and Medical Imageology(Electronic Edition)
关键词
胃底腺黏膜型腺癌
临床病理特征
免疫组织化学
诊断
鉴别诊断
Gastric adenocarcinoma of fundic gland mucosa type
Clinicopathological features
Immunohistochemistry
Diagnosis
Differential diagnosis
