摘要
目的研究缬草Valeriana officinalis L.的化学成分。方法缬草80%乙醇提取物采用硅胶、Sephadex LH-20、半制备HPLC进行分离纯化,根据理化性质、波谱数据及单晶X射线衍射鉴定所得化合物的结构。结果从中分离得到10个化合物,分别鉴定为8-acetoxyl-pathchouli alcohol(1)、n-hexacos-5,8,11-trienoic acid(2)、4-epipenlanbutenolide(3)、xylariamide(4)、(2R,3S)-3-methyl-2-(5-oxo-2-isopropenylhexyl)-cyclopentanone(5)、木蜡酸(6)、棕榈酸(7)、豆甾醇(8)、月桂酸(9)、bis(4-hydroxyphenyl)methanol(10)。结论化合物2~4为首次从缬草属中分离得到,化合物1、6、9为首次从该植物中分离得到,首次得到化合物1的单晶X射线衍射晶体结构数据。
AIM To study the chemical constituents from Valeriana officinalis L.METHODS The 80%ethanol extract from V.officinalis was isolated and purified by silica,Sephadex LH-20 and semi-preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties,spectral data and single crystal X-ray diffraction.RESULTS Ten compounds were isolated and identified as 8-acetoxyl-pathchouli alcohol(1),n-hexacos-5,8,11-trienoic acid(2),4-epipenlanButenolide(3),xylariamide(4),(2R,3S)-3-methyl-2-(5-oxo-2-isopropenyl-hexyl)-cyclopentanone(5),lignoceric acid(6),palmitic acid(7),stigmasterol(8),dodecanoic acid(9),bis(4-hydroxyphenyl)methanol(10).CONCLUSION Compounds 2-4 are identified from genus Valeriana for the first time.Compounds 1,6,9 are isolated from this plant for the first time.The crystal structure data of compound 1 by single crystal X-ray diffraction are obtained for the first time.
作者
樊浩
李玉泽
严淑婷
黄文丽
张化为
姜祎
邓翀
宋小妹
FAN Hao;LI Yu-ze;YAN Shu-ting;HUANG Wen-li;ZHANG Hua-wei;JIANG Yi;DENG Chong;SONG Xiao-mei(School of Pharmacy,Shaanxi University of Chinese Medicine,Xianyang 712046,China;Shaanxi Key Laboratory of Traditional Chinese Medicine Foundation and New Drug Research,Xianyang 712046,China)
出处
《中成药》
CAS
CSCD
北大核心
2020年第11期2930-2934,共5页
Chinese Traditional Patent Medicine
基金
陕西省科技厅项目(2019ZDLSF04-03-02)
陕西中医药大学学科创新团队项目(2019-YL12)。
关键词
缬草
化学成分
分离鉴定
单晶X射线衍射
Valeriana officinalis L.
chemical constituents
isolation and identification
single crystal X-ray diffraction
