摘要
目的分析鹊炎灵方对子宫内膜异位症(EMS)患者糖类抗原125(CA125)及卵泡刺激素(FSH)水平的影响及安全性。方法选取2018年8月-2019年8月妇科收治的EMS患者180例,通过随机数字表法随机分为观察组与对照组,各90例。对照组采用散结镇痛胶囊治疗,观察组采用鹊炎灵方进行治疗,2组均持续治疗3个月。比较2组的血清因子水平、性激素水平、疗效及不良反应。结果治疗后2组CA125、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均降低(P <0.05),且观察组以上血清因子水平低于对照组[(21.53±6.23)IU/mL vs(38.34±8.95)IU/mL、(17.23±3.64)ng/L vs(27.53±4.37)ng/L、(7.84±1.61)mg/L vs(15.42±2.74)mg/L,P <0.05]。观察组临床总有效率高于对照组(92.22%vs 81.11%, P <0.05)。治疗后,2组FSH、黄体生成素(LH)、雌二醇(E2)和孕激素(P)水平均降低(P <0.05),且观察组低于对照组[(1.69±0.48)U/L vs(2.07±0.76)U/L、(1.79±0.58)U/L vs(2.23±0.89)U/L、(111.53±17.32)pmol/L vs(137.63±23.64)pmol/L、(124.72±23.11)nmol/L vs(187.84±39.57)nmol/L,P <0.05]。观察组不良反应发生率低于对照组(5.56%vs 14.44%, P <0.05)。结论鹊炎灵方可改善EMS患者性激素水平,抑制机体炎症反应,用药安全性与常规治疗相当。
Objective To explore the effect of Queyanling recipe on the levels of carbohydrate antigen(CA125) and follicular stimulating hormone(FSH) in patients with endometriosis(EMS) and its safety. Methods 180 patients with EMS treated in our hospital between August 2018 and August 2019 were randomly divided into the observation group(n=90) and the control group(n=90). The control group was treated with Sanjie Analgesia capsule, and the observation group was treated with Queyanling recipe, all the patients were treated for 3 months. The levels of serum factor, sex hormone, curative effect and adverse reactions were compared between the two groups. Results After treatment, the levels of CA125, interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) in both groups were decreased(P<0.05), and the levels of serum factors in the observation group were lower than those in the control group [(21.53±6.23) IU/mL vs(38.34±8.95) IU/mL,(17.23±3.64) ng/L vs(27.53±4.37) ng/L,(7.84±1.61) mg/L vs(15.42±2.74) mg/L, P<0.05]. After treatment, the levels of estrogen(E2) and progesterone(P) in follicular stimulating hormone(FSH), luteinizing hormone(LH) all decreased in both groups, and the levels of above sex hormones in the observation group were lower than those in the control group [(1.69±0.48) U/L vs(2.07±0.76) U/L,(1.79±0.58) U/L vs(2.23±0.89) U/L,(111.53±17.32) pmol/L vs(137.63±23.64) pmol/L,(124.72±23.11) nmol/L vs(187.84±39.57) nmol/L,P<0.05]. The total effective rate of the patients in the observation group was higher than that in the control group(92.22% vs 81.11%, P<0.05). The incidence of adverse reactions in the observation group was lower than that in the control group(5.56% vs 14.44%, P<0.05). Conclusion The Queyanling recipe can improve the sex hormone level of the EMS patients, inhibit the inflammation reaction of the body, and the safety of the medicine is comparable to that of the conventional treatment.
作者
袁红亮
刘冰
刘秀艳
YUAN Hongliang;LIU Bing;LIU Xiuyan(Qinhuangdao Traditional Chinese Medicine Hospital,Qinhuangdao 066000,Hebei Province,China)
出处
《吉林中医药》
2020年第10期1315-1318,共4页
Jilin Journal of Chinese Medicine
