摘要
目的探讨松龄血脉康胶囊联合氟桂利嗪治疗慢性脑供血不足的临床疗效。方法选取2016年9月—2018年9月新疆心脑血管病医院158例慢性脑供血不足患者作为研究对象,根据随机抽签原则将患者分为对照组和观察组,每组各79例。对照组患者口服盐酸氟桂利嗪胶囊,1粒/次,1次/d;观察组患者在对照组的基础上口服松龄血脉康胶囊,1.5 g/次,3次/d。两组患者均连续治疗2个月。观察两组患者的临床疗效,同时比较两组治疗前后的脑血流速度和血脂水平。结果治疗后,观察组患者总有效率为93.67%,对照组患者总有效率为77.22%,两组比较存在统计学差异(P<0.05)。治疗后,两组患者的各动脉血流速度均明显升高(P<0.05),且观察组各动脉血流速度显著高于对照组(P<0.05)。治疗后,两组患者高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)和胆固醇(TC)水平均明显改善(P<0.05),且观察组血脂水平显著优于对照组(P<0.05)。结论松龄血脉康胶囊联合氟桂利嗪可有效改善患者的脑血流速度及血脂水平,临床疗效显著,在慢性脑供血不足治疗中具有较高的应用价值。
Objective To investigate the clinical effect of Songling Xuemakang Capsules combined with flunarizine in treatment of chronic cerebral insufficiency.Methods A total of 158 patients with chronic cerebral insufficiency in Xinjiang Cardiovascular and Vascular Disease Hospital from September 2016 to September 2018 were selected as the research objects, and the patients were divided into the control group and the observation group according to the principle of random lottery, with 79 patients in each group.Patients in the control group were po administered with Flunarizine Hydrochloride Capsules, 1 capsule/time, once daily.Patients in the observation group were po administered with Songling Xuemakang Capsules on the basis of control group, 1.5 g/time, three times daily.Two groups of patients were treated for 2 months.After treatment, the clinical efficacy in two groups were observed, and the cerebral blood flow velocity and blood lipid level before and after treatment were compared.Results After treatment, the total effective rate was 93.67% in the observation group and 77.22% in the control group, showing statistical difference between the two groups(P < 0.05).After treatment, the blood flow velocity of each artery in two groups was significantly increased(P < 0.05), and the blood flow velocity of each artery in the observation group was significantly higher than those in the control group(P < 0.05).After treatment, the levels of HDL-C, LDL-C, TG and TC in two groups were significantly improved(P < 0.05), and the lipid level in the observation group was significantly better than that in the control group(P < 0.05).Conclusion Songling Xuemaikang Capsules combined with flunarizine can effectively improve the cerebral blood flow velocity and blood lipid level of patients, with significant clinical efficacy, and has high application value in the treatment of chronic cerebral insufficiency.
作者
崔红莉
马大亮
幸世峰
CUI Hongli;MA Daliang;XING Shifeng(Department of Neurology,Xinjiang Cardiovascular and Vascular Disease Hospital,Urumqi 830000,China;Encephalopathy Center,Xinjiang Uygur Autonomous Region Hospital of Occupational Diseases,Urumqi 830000,China;Department of Cardiology,The Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China)
出处
《药物评价研究》
CAS
2020年第10期2053-2056,共4页
Drug Evaluation Research
关键词
松龄血脉康胶囊
氟桂利嗪
慢性脑供血不足
脑血流速度
血脂水平
Songling Xuemaikang Capsules
flunarizine
chronic cerebral insufficiency
cerebral blood flow velocity
blood lipid
