摘要
银屑病是一种系统性炎症性疾病,炎症性肠病是银屑病的主要合并症之一。流行病学研究显示,银屑病患者发生克罗恩病和炎症性肠病的风险高于普通人群,但银屑病和炎症性肠病的关系仍不明确。银屑病和炎症性肠病有许多共通的基因位点,且在炎症途径中也有重叠。尽管两者之间共同的病理生理途径,但生物治疗治疗炎症性肠病的后可能出现银屑病样皮损,银屑病患者接受生物制剂治疗后也有发生炎症性肠病的报道。因此,本综述围绕银屑病与炎症性肠病的流行病学、两者相关的病理生理机制、生物制剂治疗逐一展开。
Psoriasis is a systemic inflammatory disease,and inflammatory bowel disease is one of the major complications of psoriasis.The risk of Crohn's disease and inflammatory bowel disease in patients with psoriasis is higher than that of the general population.,but the relationship between psoriasis and inflammatory bowel disease is still unclear.Several common gene loci are reported between psoriasis and inflammatory bowel disease.There are also overlaps in inflammatory pathways.Despite the conmon pathophysiological approach between these two diseases,psoriasis-like skin lesions may appear after biological treatment of inflammatory bowel disease,and inflammatory bowel disease has also been reported in patients with psoriasis after receiving biological treatment.Therefore,this review focuses on the epidemiology of psoriasis and inflammatory bowel disease,their related pathophysiological mechanisms,and the treatment of biological agents.
作者
徐梦骏
郑敏
XU Mengjun;ZHENG Ming(Department of Dermatology,Second Afiliated Hospital of Zhejiang Universitry,Hangzhou,Zhejiang 310009)
出处
《皮肤科学通报》
2020年第5期477-479,M0003,共4页
Dermatology Bulletin
关键词
银屑病
炎症性肠病
溃疡性结肠炎
克罗恩病
生物制剂
Psoriasis
Inflammatory bowel disease
Ulcerative colitis
Crohn's disease
Biologics
