摘要
目的:建立测定供注射用活性炭中Zn、Mg、Al、Ca、V、Cr、Mn、Fe、Co、Ni、Cu、As、Se、Ag、Cd、Cs、Ba、Pb等18种重金属元素含量的方法。方法:样品经微波消解处理,采用电感耦合等离子体质谱法以45Sc、72Ge、115In、209Bi为内标元素测定18种金属元素。结果:各元素在10~1000 ng/mL范围内线性良好(r≥0.9990);检测限为0.01359~13.89 ng/mL;精密度、稳定性、重复性的RSD<6.0%;各元素平均加样回收率为91.78%~102.34%,RSD为3.07%~7.33%。结论:该方法线性回归良好、灵敏度高、准确性好,适用于供注射用活性炭中痕量金属元素的检测分析。
Objective:To establish a method for the contents determination of Zn,Mg,Al,Ca,V,Cr,Mn,Fe,Co,Ni,Cu,As,Se,Ag,Cd,Cs,Ba,Pb in Activated carbon(for injection).Methods:After digested by microwave digestion,the metal elements were determined by inductively coupled plasma mass spectrometry(ICP-MS)with 45Sc,72Ge,115In and 209Bi as internal standard elements.Results:The linear range of the metal elements were 10-1000 ng/mL(r≥0.9990);RSDs of precision,stability and reproducibility tests were lower than 6.0%;The average recovery of each element were 91.78%~102.34%,RSDs were 3.07%~7.33%.Conclusion:The method with good linear ralationship,sensitivity and accuracy,suitable for detection of trace metal elements in the analysis of Activated carbon(for injection).
作者
钟振华
夏红英
王鹏
程奇珍
ZHONG Zhenhua;XIA Hongying;WANG Peng;CHENG Qizhen(Jiangxi Institute for Drug Control,NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine,Jiangxi Province Engineering Research Center of Drug and Medical Device Quality,Nanchang 330029,China)
出处
《药品评价》
CAS
2020年第15期31-33,39,共4页
Drug Evaluation
基金
江西省食品药品监督管理局科研项目(2016YP16)。
关键词
供注射用活性炭
微波消解-电感耦合等离子体质谱
金属元素
Activated Carbon(for injection)
Microwave Digestion-Inductively Coupled Plasma Mass Spectrometry
Metal Elements
