摘要
干细胞具有自我更新和多向分化的能力,在治疗糖尿病、脑损伤、急性心梗等疾病的治疗中有着巨大的潜力。由于干细胞产品种类繁多、批次差异性大、性质复杂,因此干细胞产品临床前的质量控制尤为重要。干细胞作为活性外源物质具有免疫原性,免疫缺陷小鼠和人源化小鼠在干细胞质量控制中发挥极大作用。本文综述了干细胞的免疫学特性、总结了常用的免疫缺陷和人源化小鼠模型,概述了免疫缺陷和人源化小鼠模型在干细胞质量控制中的应用,以期为干细胞质量控制标准化提供资料和信息。
Stem cells self-renew,undergo multidirectional differentiation,and have great therapeutic potential for diabetes,brain injury,and acute myocardial infarction as examples.There are many types of stem cell products and many variations among batches.Therefore,quality control is particularly important for stem cell products before clinical use.Stem cells are immunogenic as living exogenous cells,and immunodeficient and humanized mice play an important role in stem cell quality control.Here,we review stem cell immunogenicities,summarize the commonly used immunodeficient and humanized mice,and outline the model applications of stem cell quality control to provide for a reference for stem cell quality control.
作者
石桂英
白琳
SHI Guiying;BAI Lin(Institute of Laboratory Key Laboratory of Human Disease Sciences,Chinese Academy of Medical Sciences(CAMS),Comparative Medicine Center,Peking Union College(PUMC),Key Laboratory of Human Disease Comparative Medicine,National Health Commission of the People’s Republic of China,Key Laboratory of Human Disease Key Laboratory of Human Disease Models,State Administration of Traditional Chineses Medicine,Beijing 100021,China)
出处
《中国比较医学杂志》
CAS
北大核心
2020年第10期132-137,共6页
Chinese Journal of Comparative Medicine
基金
中国医学科学院医学与健康科技创新工程项目(2019-12M-1-006)。
关键词
免疫缺陷小鼠
人源化小鼠
干细胞
质控
immunodeficient mice
humanized mice
stem cell
quality control
